Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt

Ahmed A. Ismail, Matthew R. Bonner, Olfat Hendy, Gaafar Abdel Rasoul, Kai Wang, James R. Olson, Diane Rohlman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pesticide-exposed adolescents may have a higher risk of neurotoxic effects because of their developing brains and bodies. However, only a limited number of studies have addressed this risk among adolescents. The aim of this study was to compare neurological outcomes from two cohorts of Egyptian adolescents working as pesticide applicators. In 2005 and 2009, two cohorts of male adolescents working as pesticide applicators for the cotton crop were recruited from Menoufia Governorate, Egypt. The same application schedule and pesticides were used at both times, including both organophosphorus, and pyrethroid compounds. Participants in both cohorts completed three neurobehavioral tests, health and exposure questionnaires, and medical and neurological screening examinations. In addition, blood samples were collected to measure butyryl cholinesterase (BChE) activity. Pesticide applicators in both cohorts reported more neurological symptoms and signs than non-applicators, particularly among participants in the 2005 cohort (OR ranged from 1.18 to 15.3). Except for one test (Trail Making B), there were no significant differences between either applicators or non-applicators of both cohorts on the neurobehavioral outcome measures (p > 0.05). The 2005 cohort showed greater inhibition of serum BChE activity than the 2009 cohort (p < 0.05). In addition, participants with depressed BChE activity showed more symptoms and signs than others without BChE depression (p < 0.05). Our study is the first to examine the consistency of health outcomes associated with pesticide exposure across two cohorts tested at different times from the same geographical region in rural Egypt. This similar pattern of findings across the two cohorts provides strong evidence of the health impact of exposure of adolescents to pesticides.

Original languageEnglish (US)
Article numbere0172696
JournalPLoS One
Volume12
Issue number2
DOIs
StatePublished - Feb 1 2017

Fingerprint

Egypt
Pesticides
cholinesterase
pesticides
Health
Applicators
Cholinesterases
signs and symptoms (plants)
Signs and Symptoms
pyrethrins
blood serum
Organophosphorus Compounds
Trail Making Test
Geographical regions
rural areas
Pyrethrins
questionnaires
Neurologic Examination
cotton
testing

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Ismail, A. A., Bonner, M. R., Hendy, O., Rasoul, G. A., Wang, K., Olson, J. R., & Rohlman, D. (2017). Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt. PLoS One, 12(2), [e0172696]. https://doi.org/10.1371/journal.pone.0172696

Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt. / Ismail, Ahmed A.; Bonner, Matthew R.; Hendy, Olfat; Rasoul, Gaafar Abdel; Wang, Kai; Olson, James R.; Rohlman, Diane.

In: PLoS One, Vol. 12, No. 2, e0172696, 01.02.2017.

Research output: Contribution to journalArticle

Ismail, AA, Bonner, MR, Hendy, O, Rasoul, GA, Wang, K, Olson, JR & Rohlman, D 2017, 'Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt', PLoS One, vol. 12, no. 2, e0172696. https://doi.org/10.1371/journal.pone.0172696
Ismail, Ahmed A. ; Bonner, Matthew R. ; Hendy, Olfat ; Rasoul, Gaafar Abdel ; Wang, Kai ; Olson, James R. ; Rohlman, Diane. / Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt. In: PLoS One. 2017 ; Vol. 12, No. 2.
@article{3a28966b4b064058b1d23e57344c6048,
title = "Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt",
abstract = "Pesticide-exposed adolescents may have a higher risk of neurotoxic effects because of their developing brains and bodies. However, only a limited number of studies have addressed this risk among adolescents. The aim of this study was to compare neurological outcomes from two cohorts of Egyptian adolescents working as pesticide applicators. In 2005 and 2009, two cohorts of male adolescents working as pesticide applicators for the cotton crop were recruited from Menoufia Governorate, Egypt. The same application schedule and pesticides were used at both times, including both organophosphorus, and pyrethroid compounds. Participants in both cohorts completed three neurobehavioral tests, health and exposure questionnaires, and medical and neurological screening examinations. In addition, blood samples were collected to measure butyryl cholinesterase (BChE) activity. Pesticide applicators in both cohorts reported more neurological symptoms and signs than non-applicators, particularly among participants in the 2005 cohort (OR ranged from 1.18 to 15.3). Except for one test (Trail Making B), there were no significant differences between either applicators or non-applicators of both cohorts on the neurobehavioral outcome measures (p > 0.05). The 2005 cohort showed greater inhibition of serum BChE activity than the 2009 cohort (p < 0.05). In addition, participants with depressed BChE activity showed more symptoms and signs than others without BChE depression (p < 0.05). Our study is the first to examine the consistency of health outcomes associated with pesticide exposure across two cohorts tested at different times from the same geographical region in rural Egypt. This similar pattern of findings across the two cohorts provides strong evidence of the health impact of exposure of adolescents to pesticides.",
author = "Ismail, {Ahmed A.} and Bonner, {Matthew R.} and Olfat Hendy and Rasoul, {Gaafar Abdel} and Kai Wang and Olson, {James R.} and Diane Rohlman",
year = "2017",
month = "2",
day = "1",
doi = "10.1371/journal.pone.0172696",
language = "English (US)",
volume = "12",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

TY - JOUR

T1 - Comparison of neurological health outcomes between two adolescent cohorts exposed to pesticides in Egypt

AU - Ismail, Ahmed A.

AU - Bonner, Matthew R.

AU - Hendy, Olfat

AU - Rasoul, Gaafar Abdel

AU - Wang, Kai

AU - Olson, James R.

AU - Rohlman, Diane

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Pesticide-exposed adolescents may have a higher risk of neurotoxic effects because of their developing brains and bodies. However, only a limited number of studies have addressed this risk among adolescents. The aim of this study was to compare neurological outcomes from two cohorts of Egyptian adolescents working as pesticide applicators. In 2005 and 2009, two cohorts of male adolescents working as pesticide applicators for the cotton crop were recruited from Menoufia Governorate, Egypt. The same application schedule and pesticides were used at both times, including both organophosphorus, and pyrethroid compounds. Participants in both cohorts completed three neurobehavioral tests, health and exposure questionnaires, and medical and neurological screening examinations. In addition, blood samples were collected to measure butyryl cholinesterase (BChE) activity. Pesticide applicators in both cohorts reported more neurological symptoms and signs than non-applicators, particularly among participants in the 2005 cohort (OR ranged from 1.18 to 15.3). Except for one test (Trail Making B), there were no significant differences between either applicators or non-applicators of both cohorts on the neurobehavioral outcome measures (p > 0.05). The 2005 cohort showed greater inhibition of serum BChE activity than the 2009 cohort (p < 0.05). In addition, participants with depressed BChE activity showed more symptoms and signs than others without BChE depression (p < 0.05). Our study is the first to examine the consistency of health outcomes associated with pesticide exposure across two cohorts tested at different times from the same geographical region in rural Egypt. This similar pattern of findings across the two cohorts provides strong evidence of the health impact of exposure of adolescents to pesticides.

AB - Pesticide-exposed adolescents may have a higher risk of neurotoxic effects because of their developing brains and bodies. However, only a limited number of studies have addressed this risk among adolescents. The aim of this study was to compare neurological outcomes from two cohorts of Egyptian adolescents working as pesticide applicators. In 2005 and 2009, two cohorts of male adolescents working as pesticide applicators for the cotton crop were recruited from Menoufia Governorate, Egypt. The same application schedule and pesticides were used at both times, including both organophosphorus, and pyrethroid compounds. Participants in both cohorts completed three neurobehavioral tests, health and exposure questionnaires, and medical and neurological screening examinations. In addition, blood samples were collected to measure butyryl cholinesterase (BChE) activity. Pesticide applicators in both cohorts reported more neurological symptoms and signs than non-applicators, particularly among participants in the 2005 cohort (OR ranged from 1.18 to 15.3). Except for one test (Trail Making B), there were no significant differences between either applicators or non-applicators of both cohorts on the neurobehavioral outcome measures (p > 0.05). The 2005 cohort showed greater inhibition of serum BChE activity than the 2009 cohort (p < 0.05). In addition, participants with depressed BChE activity showed more symptoms and signs than others without BChE depression (p < 0.05). Our study is the first to examine the consistency of health outcomes associated with pesticide exposure across two cohorts tested at different times from the same geographical region in rural Egypt. This similar pattern of findings across the two cohorts provides strong evidence of the health impact of exposure of adolescents to pesticides.

UR - http://www.scopus.com/inward/record.url?scp=85013634990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013634990&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0172696

DO - 10.1371/journal.pone.0172696

M3 - Article

C2 - 28231336

AN - SCOPUS:85013634990

VL - 12

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 2

M1 - e0172696

ER -