Comparison of mortality in women versus men with infections involving cardiovascular implantable electronic device

M. Rizwan Sohail, Charles Henrikson, Mary Jo Braid-Forbes, Kevin F. Forbes, Daniel J. Lerner

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Device infection is a complication of implantable cardioverter- defibrillator (ICD) therapy that significantly increases mortality. Risk factors associated with death and ICD infection are poorly understood. The purpose of this study was to identify patient characteristics associated with death after cardiovascular implantable electronic device (CIED) infection. This is a retrospective cohort study of 64,903 Medicare fee-for-service patients who received an ICD in 2007, including 1,855 with device infection. Long-term survival was significantly reduced with CIED infection (71.6% vs 85.0%, p 45%. Importantly, a substantial portion of this excess mortality occurred after the index admission for infection, when the hazard ratio for death in women compared with that in men increased from 0.86 (95% CI 0.82 to 0.91) to 1.20 (95% CI 0.96 to 1.51) with CIED infection, despite little gender difference in admission length of stay, disposition, and cost. In conclusion, women are significantly more likely than men to die with CIED infection. A substantial part of this excess mortality occurs after discharge. It will be important to identify and address the cause(s) of this gender difference in mortality.

    Original languageEnglish (US)
    Pages (from-to)1403-1409
    Number of pages7
    JournalAmerican Journal of Cardiology
    Volume112
    Issue number9
    DOIs
    StatePublished - Nov 1 2013

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    Cardiovascular Infections
    Equipment and Supplies
    Mortality
    Infection
    Implantable Defibrillators
    Fee-for-Service Plans
    Medicare
    Length of Stay
    Cohort Studies
    Retrospective Studies
    Costs and Cost Analysis

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Comparison of mortality in women versus men with infections involving cardiovascular implantable electronic device. / Sohail, M. Rizwan; Henrikson, Charles; Braid-Forbes, Mary Jo; Forbes, Kevin F.; Lerner, Daniel J.

    In: American Journal of Cardiology, Vol. 112, No. 9, 01.11.2013, p. 1403-1409.

    Research output: Contribution to journalArticle

    Sohail, M. Rizwan ; Henrikson, Charles ; Braid-Forbes, Mary Jo ; Forbes, Kevin F. ; Lerner, Daniel J. / Comparison of mortality in women versus men with infections involving cardiovascular implantable electronic device. In: American Journal of Cardiology. 2013 ; Vol. 112, No. 9. pp. 1403-1409.
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