Comparison of maternal and fetal chromosome heteromorphisms to monitor maternal cell contamination in chorionic villus samples

Susan Olson; John Buckmaster; John Bissonnette; Ellen Magenis

doi:10.1002/pd.1970070607

Comparison of maternal and fetal chromosome heteromorphisms to monitor maternal cell contamination in chorionic villus samples

Susan Olson, John Buckmaster, John Bissonnette, Ellen Magenis

Molecular and Medical Genetics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Maternal cell contamination (MCC) presents a potential problem in the analysis of chorionic villus sampling (CVS) preparations for early prenatal diagnosis by chromosomal, biochemical and molecular methods. Through the comparison of fluorescent chromosome variants from CVS and maternal cells, we found three out of 50 samples to have MCC. One of these was observed on a direct preparation. Routine chromosome heteromorphism analysis suggested as a reliable method for monitoring MCC in CVS specimens.

Original language	English (US)
Pages (from-to)	413-417
Number of pages	5
Journal	Prenatal Diagnosis
Volume	7
Issue number	6
DOIs	https://doi.org/10.1002/pd.1970070607
State	Published - Jul 1987

Keywords

Chorionic villus sampling
Chromosome heteromorphisms
Maternal cell contamination
Prenatal diagnosis

ASJC Scopus subject areas

Obstetrics and Gynecology
Genetics(clinical)

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10.1002/pd.1970070607

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abstract = "Maternal cell contamination (MCC) presents a potential problem in the analysis of chorionic villus sampling (CVS) preparations for early prenatal diagnosis by chromosomal, biochemical and molecular methods. Through the comparison of fluorescent chromosome variants from CVS and maternal cells, we found three out of 50 samples to have MCC. One of these was observed on a direct preparation. Routine chromosome heteromorphism analysis suggested as a reliable method for monitoring MCC in CVS specimens.",

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AU - Buckmaster, John

AU - Bissonnette, John

AU - Magenis, Ellen

PY - 1987/7

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N2 - Maternal cell contamination (MCC) presents a potential problem in the analysis of chorionic villus sampling (CVS) preparations for early prenatal diagnosis by chromosomal, biochemical and molecular methods. Through the comparison of fluorescent chromosome variants from CVS and maternal cells, we found three out of 50 samples to have MCC. One of these was observed on a direct preparation. Routine chromosome heteromorphism analysis suggested as a reliable method for monitoring MCC in CVS specimens.

AB - Maternal cell contamination (MCC) presents a potential problem in the analysis of chorionic villus sampling (CVS) preparations for early prenatal diagnosis by chromosomal, biochemical and molecular methods. Through the comparison of fluorescent chromosome variants from CVS and maternal cells, we found three out of 50 samples to have MCC. One of these was observed on a direct preparation. Routine chromosome heteromorphism analysis suggested as a reliable method for monitoring MCC in CVS specimens.

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KW - Chromosome heteromorphisms

KW - Maternal cell contamination

KW - Prenatal diagnosis

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Comparison of maternal and fetal chromosome heteromorphisms to monitor maternal cell contamination in chorionic villus samples

Abstract

Keywords

ASJC Scopus subject areas

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