Comparison of maternal and fetal chromosome heteromorphisms to monitor maternal cell contamination in chorionic villus samples

Susan Olson, John Buckmaster, John Bissonnette, Ellen Magenis

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Maternal cell contamination (MCC) presents a potential problem in the analysis of chorionic villus sampling (CVS) preparations for early prenatal diagnosis by chromosomal, biochemical and molecular methods. Through the comparison of fluorescent chromosome variants from CVS and maternal cells, we found three out of 50 samples to have MCC. One of these was observed on a direct preparation. Routine chromosome heteromorphism analysis suggested as a reliable method for monitoring MCC in CVS specimens.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalPrenatal Diagnosis
Volume7
Issue number6
DOIs
StatePublished - Jul 1987

Keywords

  • Chorionic villus sampling
  • Chromosome heteromorphisms
  • Maternal cell contamination
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)

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