Comparison of lactate, base excess, bicarbonate, and pH as predictors of mortality after severe trauma in rhesus macaques (Macaca mulatta)

Theodore Hobbs, Jean P. O'Malley, Samone Khouangsathiene, Christopher J. Dubay

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    Social group housing of rhesus macaques at biomedical facilities is advocated to improve the psychologic wellbeing of these intelligent and social animals. An unintended outcome of social housing in this species is increased intraspecific aggression resulting in cases of severe multiple trauma and posttraumatic shock. The metabolic correlates of oxygen debt are likely important quantifiers of the severity of posttraumatic shock and may serve as useful guides in the treatment of these cases. The purpose of this retrospective study was to evaluate venous blood lactate, base excess, bicarbonate, and pH as predictors of mortality. These 4 variables were assessed in 84 monkeys with severe traumatic injury and shock. Data were available from blood samples collected prior to resuscitation therapy and the day after resuscitation therapy. The pre- and postresuscitation therapy levels of the variables then were tested for association with 6-d survival. When measured prior to resuscitation therapy, all variables were strongly correlated with each other and had a statistically significant association with survival. No single variable had both strong specificity and high sensitivity when measured prior to resuscitation therapy. Survival analysis showed that as the number of categorical indicators of acidosis increased, 6-d survival decreased. Analysis of the 4 variables after resuscitation therapy indicated that lactate was the only variable significantly associated with survival in our study.

    Original languageEnglish (US)
    Pages (from-to)233-239
    Number of pages7
    JournalComparative Medicine
    Volume60
    Issue number3
    StatePublished - 2010

    Fingerprint

    Resuscitation
    Bicarbonates
    Macaca mulatta
    bicarbonates
    lactates
    Lactic Acid
    therapeutics
    Mortality
    Wounds and Injuries
    Blood
    public housing
    Therapeutics
    Shock
    group housing
    debt
    Traumatic Shock
    blood
    acidosis
    Multiple Trauma
    retrospective studies

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • veterinary(all)
    • Medicine(all)

    Cite this

    Comparison of lactate, base excess, bicarbonate, and pH as predictors of mortality after severe trauma in rhesus macaques (Macaca mulatta). / Hobbs, Theodore; O'Malley, Jean P.; Khouangsathiene, Samone; Dubay, Christopher J.

    In: Comparative Medicine, Vol. 60, No. 3, 2010, p. 233-239.

    Research output: Contribution to journalArticle

    Hobbs, Theodore ; O'Malley, Jean P. ; Khouangsathiene, Samone ; Dubay, Christopher J. / Comparison of lactate, base excess, bicarbonate, and pH as predictors of mortality after severe trauma in rhesus macaques (Macaca mulatta). In: Comparative Medicine. 2010 ; Vol. 60, No. 3. pp. 233-239.
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