Comparison of human leukocyte antigen DR-DQ disease associations found with cervical dysplasia and invasive cervical carcinoma

Raymond J. Apple, Thomas Becker, Cosette M. Wheeler, Henry A. Erlich

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Background: Human leukocyte antigen (HLA) molecules, whose biological role is in the regulation of immune responses to foreign antigens and in discrimination of self from non-self antigens, are encoded by a series of closely linked genetic loci found on chromosome 6. Although the evidence for a link between HLA and cervical cancer has been controversial, it has been recently reported that certain HLA class II haplotypes (linked class II alleles) are positively associated with invasive cervical cancer, while other class II haplotypes are negatively associated or protective. Since HLA associations between human papillomavirus type 16 (HPV16)-mediated cancer cases and non-HPV16-mediated cancer cases have been found to be different, this suggests that specific HLA class II haplotypes may influence the immune response to HPV infection and may affect the risk of acquiring invasive cervical carcinoma. Purpose: This study was conducted to determine if the same HLA class II haplotypes that are associated with invasive cervical carcinoma are also associated with cervical dysplasia (pre-sumed precursors of invasive cervical cancer). Methods: We have examined HLA DR-DQ haplotypes among 128 Hispanic women from New Mexico with biopsy-confirmed cervical dysplasia in a case-control study using sensitive DNA-based polymerase chain reaction amplification and sequence-specific oligonucleotide probe hybridization methods to detect the presence and type of HPV and to detect allelic polymorphism in the HLA DRB1 and DQB1 loci. Results: Dysplasia cases were divided into two groups for comparison to controls: severe dysplasia/carcinoma in situ (CIS), and slight/moderate dysplasia. The frequency distribution of HLA class II haplotypes among the HPV16-positive severe dysplasia/CIS cases had a statistically significant (two-tailed P

Original languageEnglish (US)
Pages (from-to)427-436
Number of pages10
JournalJournal of the National Cancer Institute
Volume87
Issue number6
DOIs
StatePublished - Mar 15 1995
Externally publishedYes

Fingerprint

Uterine Cervical Dysplasia
Leukocytes
Antigens
HLA Antigens
Carcinoma
Haplotype
Haplotypes
Cancer
Uterine Cervical Neoplasms
Human papillomavirus 16
Carcinoma in Situ
Immune Response
Locus
Human
Chromosomes, Human, Pair 6
Genetic Loci
Oligonucleotide Probes
DNA-Directed DNA Polymerase
Polymerase Chain Reaction
Hispanic Americans

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Oncology
  • Cancer Research

Cite this

Comparison of human leukocyte antigen DR-DQ disease associations found with cervical dysplasia and invasive cervical carcinoma. / Apple, Raymond J.; Becker, Thomas; Wheeler, Cosette M.; Erlich, Henry A.

In: Journal of the National Cancer Institute, Vol. 87, No. 6, 15.03.1995, p. 427-436.

Research output: Contribution to journalArticle

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