Comparison of complications in free flap reconstruction for osteoradionecrosis in patients with or without hyperbaric oxygen therapy

David Nolen, Steven B. Cannady, Mark K. Wax, Joseph Scharpf, Liana Puscas, Ramon M. Esclamado, Michael Fritz, John Freiberger, Walter T. Lee

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background. Hyperbaric oxygen (HBO) therapy induces native tissue oxygenation. The hypothesis was patients with mandibular osteoradionecrosis (ORN) and a history of HBO therapy would have less free flap reconstruction complications than patients without HBO therapy.

Methods. We conducted a multisite retrospective review involving radical debridement and free flap reconstruction for ORN between January 1, 1995 and June 30, 2011. Patients were stratified based on receiving prior HBO therapy or not.

Results. Thirty-nine of 89 patients (43.8%) had HBO therapy whereas 50 of 89 (56.2%) did not. The HBO therapy group had significantly less patients with diabetes. There was no statistical difference in overall complication in patients between groups (p 5 .5478). However, there was marginal significance of increased infections in the patients with a history of HBO therapy (p 5 .0545).

Conclusion. Although no significant differences in free flap reconstruction complication rates were observed between these 2 patient cohorts, there was marginal significance of increased infections in the patients with a history of HBO therapy. A prospective multi-institutional randomized study examining issues of infection would address issues inherent in this retrospective study.

Original languageEnglish (US)
Pages (from-to)1701-1704
Number of pages4
JournalHead and Neck
Volume36
Issue number12
DOIs
StatePublished - Dec 1 2014

Keywords

  • Free flap reconstruction
  • Hyperbaric oxygen
  • Osteoradionecrosis
  • Radiation complications
  • Surgical complications

ASJC Scopus subject areas

  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Comparison of complications in free flap reconstruction for osteoradionecrosis in patients with or without hyperbaric oxygen therapy'. Together they form a unique fingerprint.

  • Cite this

    Nolen, D., Cannady, S. B., Wax, M. K., Scharpf, J., Puscas, L., Esclamado, R. M., Fritz, M., Freiberger, J., & Lee, W. T. (2014). Comparison of complications in free flap reconstruction for osteoradionecrosis in patients with or without hyperbaric oxygen therapy. Head and Neck, 36(12), 1701-1704. https://doi.org/10.1002/hed.23520