Comparison of clinical, echographic, and histopathological measurements from eyes with medium-sized choroidal melanoma in the Collaborative Ocular Melanoma Study

COMS report no. 21

Marie Diener-West, Daniel Albert, Sandra Frazier Byrne, Frederick H. Davidorf, David Followill, Ronald L. Green, Barbara S. Hawkins, Peter K. Kaiser, Dennis M. Robertson, Bradley R. Straatsma

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Abstract

Objective: To compare pre-enucleation clinical and echographic measurements with postenucleation histopathological measurements of choroidal melanoma of a size and in a location suitable for iodine 125 brachytherapy. Design: Cross-sectional study of patients with melanoma classified as medium-sized who were assigned to the enucleation arm of the randomized trial of 121I brachytherapy vs enucleation conducted by the Collaborative Ocular Melanoma Study (COMS) Group. Methods: Measurements of melanoma dimensions by clinical, echographic, and histopathological examinations were compared for 644 eyes. Outcomes: Tumor longest basal diameter and apical height. Results: Tumor dimensions were available for 644 (98%) of 660 patients who had unilateral medium-sized choroidal melanoma and were randomly assigned to enucleation. The clinical and histopathological measurements of the longest basal diameter agreed within ±2 mm for 371 eyes (58%). The clinical measurement was less than the histopathological measurement by more than 2 mm in 32 eyes (5%), which occurred more frequently when the tumor was within 2 mm of the optic disc. The echographic and histopathological measurements of apical height agreed within ±2 mm in 579 eyes (90%); the echographic measurement was less than the histopathological measurement in only 2 cases. Features associated with echographic estimates larger than histopathological measurements were greater tumor height and anterior tumor apex location. Conclusions: Our results suggest that tumor measurements made according to COMS protocol were highly reliable in planning radioactive plaque therapy and monitoring changes in tumor size after such treatment.

Original languageEnglish (US)
Pages (from-to)1163-1171
Number of pages9
JournalArchives of ophthalmology
Volume121
Issue number8
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

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Melanoma
Neoplasms
Brachytherapy
Optic Disk
Iodine
Arm
Cross-Sectional Studies
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Comparison of clinical, echographic, and histopathological measurements from eyes with medium-sized choroidal melanoma in the Collaborative Ocular Melanoma Study : COMS report no. 21. / Diener-West, Marie; Albert, Daniel; Byrne, Sandra Frazier; Davidorf, Frederick H.; Followill, David; Green, Ronald L.; Hawkins, Barbara S.; Kaiser, Peter K.; Robertson, Dennis M.; Straatsma, Bradley R.

In: Archives of ophthalmology, Vol. 121, No. 8, 01.08.2003, p. 1163-1171.

Research output: Contribution to journalArticle

Diener-West, Marie ; Albert, Daniel ; Byrne, Sandra Frazier ; Davidorf, Frederick H. ; Followill, David ; Green, Ronald L. ; Hawkins, Barbara S. ; Kaiser, Peter K. ; Robertson, Dennis M. ; Straatsma, Bradley R. / Comparison of clinical, echographic, and histopathological measurements from eyes with medium-sized choroidal melanoma in the Collaborative Ocular Melanoma Study : COMS report no. 21. In: Archives of ophthalmology. 2003 ; Vol. 121, No. 8. pp. 1163-1171.
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abstract = "Objective: To compare pre-enucleation clinical and echographic measurements with postenucleation histopathological measurements of choroidal melanoma of a size and in a location suitable for iodine 125 brachytherapy. Design: Cross-sectional study of patients with melanoma classified as medium-sized who were assigned to the enucleation arm of the randomized trial of 121I brachytherapy vs enucleation conducted by the Collaborative Ocular Melanoma Study (COMS) Group. Methods: Measurements of melanoma dimensions by clinical, echographic, and histopathological examinations were compared for 644 eyes. Outcomes: Tumor longest basal diameter and apical height. Results: Tumor dimensions were available for 644 (98{\%}) of 660 patients who had unilateral medium-sized choroidal melanoma and were randomly assigned to enucleation. The clinical and histopathological measurements of the longest basal diameter agreed within ±2 mm for 371 eyes (58{\%}). The clinical measurement was less than the histopathological measurement by more than 2 mm in 32 eyes (5{\%}), which occurred more frequently when the tumor was within 2 mm of the optic disc. The echographic and histopathological measurements of apical height agreed within ±2 mm in 579 eyes (90{\%}); the echographic measurement was less than the histopathological measurement in only 2 cases. Features associated with echographic estimates larger than histopathological measurements were greater tumor height and anterior tumor apex location. Conclusions: Our results suggest that tumor measurements made according to COMS protocol were highly reliable in planning radioactive plaque therapy and monitoring changes in tumor size after such treatment.",
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T2 - COMS report no. 21

AU - Diener-West, Marie

AU - Albert, Daniel

AU - Byrne, Sandra Frazier

AU - Davidorf, Frederick H.

AU - Followill, David

AU - Green, Ronald L.

AU - Hawkins, Barbara S.

AU - Kaiser, Peter K.

AU - Robertson, Dennis M.

AU - Straatsma, Bradley R.

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N2 - Objective: To compare pre-enucleation clinical and echographic measurements with postenucleation histopathological measurements of choroidal melanoma of a size and in a location suitable for iodine 125 brachytherapy. Design: Cross-sectional study of patients with melanoma classified as medium-sized who were assigned to the enucleation arm of the randomized trial of 121I brachytherapy vs enucleation conducted by the Collaborative Ocular Melanoma Study (COMS) Group. Methods: Measurements of melanoma dimensions by clinical, echographic, and histopathological examinations were compared for 644 eyes. Outcomes: Tumor longest basal diameter and apical height. Results: Tumor dimensions were available for 644 (98%) of 660 patients who had unilateral medium-sized choroidal melanoma and were randomly assigned to enucleation. The clinical and histopathological measurements of the longest basal diameter agreed within ±2 mm for 371 eyes (58%). The clinical measurement was less than the histopathological measurement by more than 2 mm in 32 eyes (5%), which occurred more frequently when the tumor was within 2 mm of the optic disc. The echographic and histopathological measurements of apical height agreed within ±2 mm in 579 eyes (90%); the echographic measurement was less than the histopathological measurement in only 2 cases. Features associated with echographic estimates larger than histopathological measurements were greater tumor height and anterior tumor apex location. Conclusions: Our results suggest that tumor measurements made according to COMS protocol were highly reliable in planning radioactive plaque therapy and monitoring changes in tumor size after such treatment.

AB - Objective: To compare pre-enucleation clinical and echographic measurements with postenucleation histopathological measurements of choroidal melanoma of a size and in a location suitable for iodine 125 brachytherapy. Design: Cross-sectional study of patients with melanoma classified as medium-sized who were assigned to the enucleation arm of the randomized trial of 121I brachytherapy vs enucleation conducted by the Collaborative Ocular Melanoma Study (COMS) Group. Methods: Measurements of melanoma dimensions by clinical, echographic, and histopathological examinations were compared for 644 eyes. Outcomes: Tumor longest basal diameter and apical height. Results: Tumor dimensions were available for 644 (98%) of 660 patients who had unilateral medium-sized choroidal melanoma and were randomly assigned to enucleation. The clinical and histopathological measurements of the longest basal diameter agreed within ±2 mm for 371 eyes (58%). The clinical measurement was less than the histopathological measurement by more than 2 mm in 32 eyes (5%), which occurred more frequently when the tumor was within 2 mm of the optic disc. The echographic and histopathological measurements of apical height agreed within ±2 mm in 579 eyes (90%); the echographic measurement was less than the histopathological measurement in only 2 cases. Features associated with echographic estimates larger than histopathological measurements were greater tumor height and anterior tumor apex location. Conclusions: Our results suggest that tumor measurements made according to COMS protocol were highly reliable in planning radioactive plaque therapy and monitoring changes in tumor size after such treatment.

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