Comparison of antimouse and antihorse antibody production during the treatment of allograft rejection with OKT3 or antithymocyte globulin

C. F. Shield, D. J. Norman, P. Marlett, A. J. Fucello, G. Goldstein

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Antimouse antibody is produced from 40 to 68% of the time after administration of Orthoclone OKT3. In patients treated with OKT3, however, if the concomitant immunosuppression is not decreased, the incidence of the antibody production is reduced to 40%. Similarly, 33% of patients developed antihorse antibody after the initial antithymocyte globulin (ATG) administration. Most of the time, the antibody production is low-titered for both OKT3 and ATG.

Original languageEnglish (US)
Pages (from-to)48-51
Number of pages4
JournalNephron
Volume46
Issue numberSUPPL. 1
StatePublished - Sep 10 1987
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Urology
  • Physiology (medical)

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