Comparison of ABR stimuli for the early detection of ototoxicity: Conventional clicks compared with high frequency clicks and single frequency tonebursts

Stephen A. Fausti, Christopher L. Flick, Alison M. Bobal, Roger M. Ellingson, James Henry, Curtin R. Mitchell

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Effective objective testing methodology is needed for early detection of the effects of ototoxicity on hearing in patients. The requirements for such testing include responses that are: 1) reliable across test sessions; 2) sensitive to ototoxic change (> 8 kHz), and 3) recordable in a time-efficient manner. Auditory brainstem responses (ABR) appear well suited to this task however, conventional clicks stimulate primarily mid-frequencies (1-4 kHz) and high frequency tonebursts require too much time. We hypothesized that delivery of a band of high frequencies (a high frequency "click"), would elicit reliable and useful ABRs. In the current study, flat and sloped HF (high frequency) clicks with a bandwidth of 8-14 kHz were used. The purpose was to compare brainstem responses elicited by tonebursts, two HF clicks and conventional clicks. The results show that the reliability of responses to the HF clicks were comparable to the tonebursts and further, both HF clicks produced responses slightly larger than tonebursts.

Original languageEnglish (US)
Pages (from-to)239-250
Number of pages12
JournalJournal of the American Academy of Audiology
Volume14
Issue number5
StatePublished - May 2003
Externally publishedYes

Fingerprint

Brain Stem Auditory Evoked Potentials
Reproducibility of Results
Hearing
Brain Stem

Keywords

  • Auditory brainstem responses
  • Clicks
  • Ototoxicity
  • Tonebursts

ASJC Scopus subject areas

  • Speech and Hearing

Cite this

Comparison of ABR stimuli for the early detection of ototoxicity : Conventional clicks compared with high frequency clicks and single frequency tonebursts. / Fausti, Stephen A.; Flick, Christopher L.; Bobal, Alison M.; Ellingson, Roger M.; Henry, James; Mitchell, Curtin R.

In: Journal of the American Academy of Audiology, Vol. 14, No. 5, 05.2003, p. 239-250.

Research output: Contribution to journalArticle

Fausti, Stephen A. ; Flick, Christopher L. ; Bobal, Alison M. ; Ellingson, Roger M. ; Henry, James ; Mitchell, Curtin R. / Comparison of ABR stimuli for the early detection of ototoxicity : Conventional clicks compared with high frequency clicks and single frequency tonebursts. In: Journal of the American Academy of Audiology. 2003 ; Vol. 14, No. 5. pp. 239-250.
@article{e020f8aa86f74e0580daa873ae579ab9,
title = "Comparison of ABR stimuli for the early detection of ototoxicity: Conventional clicks compared with high frequency clicks and single frequency tonebursts",
abstract = "Effective objective testing methodology is needed for early detection of the effects of ototoxicity on hearing in patients. The requirements for such testing include responses that are: 1) reliable across test sessions; 2) sensitive to ototoxic change (> 8 kHz), and 3) recordable in a time-efficient manner. Auditory brainstem responses (ABR) appear well suited to this task however, conventional clicks stimulate primarily mid-frequencies (1-4 kHz) and high frequency tonebursts require too much time. We hypothesized that delivery of a band of high frequencies (a high frequency {"}click{"}), would elicit reliable and useful ABRs. In the current study, flat and sloped HF (high frequency) clicks with a bandwidth of 8-14 kHz were used. The purpose was to compare brainstem responses elicited by tonebursts, two HF clicks and conventional clicks. The results show that the reliability of responses to the HF clicks were comparable to the tonebursts and further, both HF clicks produced responses slightly larger than tonebursts.",
keywords = "Auditory brainstem responses, Clicks, Ototoxicity, Tonebursts",
author = "Fausti, {Stephen A.} and Flick, {Christopher L.} and Bobal, {Alison M.} and Ellingson, {Roger M.} and James Henry and Mitchell, {Curtin R.}",
year = "2003",
month = "5",
language = "English (US)",
volume = "14",
pages = "239--250",
journal = "Journal of the American Academy of Audiology",
issn = "1050-0545",
publisher = "American Academy of Audiology",
number = "5",

}

TY - JOUR

T1 - Comparison of ABR stimuli for the early detection of ototoxicity

T2 - Conventional clicks compared with high frequency clicks and single frequency tonebursts

AU - Fausti, Stephen A.

AU - Flick, Christopher L.

AU - Bobal, Alison M.

AU - Ellingson, Roger M.

AU - Henry, James

AU - Mitchell, Curtin R.

PY - 2003/5

Y1 - 2003/5

N2 - Effective objective testing methodology is needed for early detection of the effects of ototoxicity on hearing in patients. The requirements for such testing include responses that are: 1) reliable across test sessions; 2) sensitive to ototoxic change (> 8 kHz), and 3) recordable in a time-efficient manner. Auditory brainstem responses (ABR) appear well suited to this task however, conventional clicks stimulate primarily mid-frequencies (1-4 kHz) and high frequency tonebursts require too much time. We hypothesized that delivery of a band of high frequencies (a high frequency "click"), would elicit reliable and useful ABRs. In the current study, flat and sloped HF (high frequency) clicks with a bandwidth of 8-14 kHz were used. The purpose was to compare brainstem responses elicited by tonebursts, two HF clicks and conventional clicks. The results show that the reliability of responses to the HF clicks were comparable to the tonebursts and further, both HF clicks produced responses slightly larger than tonebursts.

AB - Effective objective testing methodology is needed for early detection of the effects of ototoxicity on hearing in patients. The requirements for such testing include responses that are: 1) reliable across test sessions; 2) sensitive to ototoxic change (> 8 kHz), and 3) recordable in a time-efficient manner. Auditory brainstem responses (ABR) appear well suited to this task however, conventional clicks stimulate primarily mid-frequencies (1-4 kHz) and high frequency tonebursts require too much time. We hypothesized that delivery of a band of high frequencies (a high frequency "click"), would elicit reliable and useful ABRs. In the current study, flat and sloped HF (high frequency) clicks with a bandwidth of 8-14 kHz were used. The purpose was to compare brainstem responses elicited by tonebursts, two HF clicks and conventional clicks. The results show that the reliability of responses to the HF clicks were comparable to the tonebursts and further, both HF clicks produced responses slightly larger than tonebursts.

KW - Auditory brainstem responses

KW - Clicks

KW - Ototoxicity

KW - Tonebursts

UR - http://www.scopus.com/inward/record.url?scp=54149118793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54149118793&partnerID=8YFLogxK

M3 - Article

C2 - 12956307

AN - SCOPUS:54149118793

VL - 14

SP - 239

EP - 250

JO - Journal of the American Academy of Audiology

JF - Journal of the American Academy of Audiology

SN - 1050-0545

IS - 5

ER -