Comparison of 3 T MRI and CT for the measurement of visceral and subcutaneous adipose tissue in humans

Bethany Klopfenstein, M. S. Kim, C. M. Krisky, J. Szumowski, William Rooney, Jonathan Purnell

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Objective: CT is considered the gold standard imaging modality for measurement of visceral adipose tissue area. However, as CT imaging exposes subjects to ionising radiation, a comparable imaging technique without this exposure is desirable, such as MRI. Therefore, we compared the agreement of measures of visceral adipose tissue and subcutaneous adipose tissue area from single-slice images obtained at the umbilicus using a 3 T MRI scanner with single-slice images obtained via CT scan. Methods: 64 images were obtained from 27 subjects who underwent MRI and CT scanning on the same day, after 10-12 hours of fasting. Visceral and subcutaneous adipose tissue depots were manually separated and quantified using a multimodality image-processing software program. Results: We found good agreement between CT and MRI for the measurement of both visceral adipose tissue and subcutaneous adipose tissue. Bland-Altman difference analysis demonstrated a mean bias of 22.9% (as a portion of total abdominal area) for visceral adipose tissue and +0.4% for subcutaneous adipose tissue, as measured by MRI compared with CT. Conclusion: MRI is a safe, accurate and precise imaging modality for measuring both visceral and subcutaneous adipose tissue, making it a favourable alternative to CT for quantification of these adipose depots.

Original languageEnglish (US)
JournalBritish Journal of Radiology
Volume85
Issue number1018
DOIs
StatePublished - Oct 2012

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Intra-Abdominal Fat
Subcutaneous Fat
Umbilicus
Ionizing Radiation
Fasting
Software

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Comparison of 3 T MRI and CT for the measurement of visceral and subcutaneous adipose tissue in humans. / Klopfenstein, Bethany; Kim, M. S.; Krisky, C. M.; Szumowski, J.; Rooney, William; Purnell, Jonathan.

In: British Journal of Radiology, Vol. 85, No. 1018, 10.2012.

Research output: Contribution to journalArticle

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abstract = "Objective: CT is considered the gold standard imaging modality for measurement of visceral adipose tissue area. However, as CT imaging exposes subjects to ionising radiation, a comparable imaging technique without this exposure is desirable, such as MRI. Therefore, we compared the agreement of measures of visceral adipose tissue and subcutaneous adipose tissue area from single-slice images obtained at the umbilicus using a 3 T MRI scanner with single-slice images obtained via CT scan. Methods: 64 images were obtained from 27 subjects who underwent MRI and CT scanning on the same day, after 10-12 hours of fasting. Visceral and subcutaneous adipose tissue depots were manually separated and quantified using a multimodality image-processing software program. Results: We found good agreement between CT and MRI for the measurement of both visceral adipose tissue and subcutaneous adipose tissue. Bland-Altman difference analysis demonstrated a mean bias of 22.9{\%} (as a portion of total abdominal area) for visceral adipose tissue and +0.4{\%} for subcutaneous adipose tissue, as measured by MRI compared with CT. Conclusion: MRI is a safe, accurate and precise imaging modality for measuring both visceral and subcutaneous adipose tissue, making it a favourable alternative to CT for quantification of these adipose depots.",
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AU - Purnell, Jonathan

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