Comparing the serum TAG response to high-dose supplementation of either DHA or EPA among individuals with increased cardiovascular risk: The ComparED study

Janie Allaire, Cécile Vors, William S. Harris, Kristina Harris Jackson, André Tchernof, Patrick Couture, Benoît Lamarche

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Studies have shown that the reduction in serum TAG concentrations with long-chain n-3 fatty acid supplementation is highly variable among individuals. The objectives of the present study were to compare the proportions of individuals whose TAG concentrations lowered after high-dose DHA and EPA, and to identify the predictors of response to both modalities. In a double-blind, controlled, crossover study, 154 men and women were randomised to three supplemented phases of 10 weeks each: (1) 2·7 g/d of DHA, (2) 2·7 g/d of EPA and (3) 3 g/d of maize oil, separated by 9-week washouts. As secondary analyses, the mean intra-individual variation in TAG was calculated using the standard deviation from the mean of four off-treatment samples. The response remained within the intra-individual variation (±0·25 mmol/l) in 47 and 57 % of participants after DHA and EPA, respectively. Although there was a greater proportion of participants with a reduction >0·25 mmol/l after DHA than after EPA (45 υ. 32 %; P < 0·001), the mean TAG reduction was comparable between groups (-0·59 (sem 0·04) υ. -0·57 (sem 0·05) mmol/l). Participants with a reduction >0·25 mmol/l after both DHA and EPA had higher non-HDL-cholesterol, TAG and insulin concentrations compared with other responders at baseline (all P < 0·05). In conclusion, supplementation with 2·7 g/d DHA or EPA had no meaningful effect on TAG concentrations in a large proportion of individuals with normal mean TAG concentrations at baseline. Although DHA lowered TAG in a greater proportion of individuals compared with EPA, the magnitude of TAG lowering among them was similar.

Original languageEnglish (US)
Pages (from-to)1223-1234
Number of pages12
JournalBritish Journal of Nutrition
Volume121
Issue number11
DOIs
StatePublished - Jun 14 2019
Externally publishedYes

Keywords

  • DHA
  • EPA
  • Intra-individual variations
  • TAG
  • Variability

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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