Comparative sensitivity of the MoCA and Mattis Dementia Rating Scale-2 in Parkinson's disease

Taylor R. Hendershott, Delphine Zhu, Seoni Llanes, Cyrus P. Zabetian, Joseph Quinn, Karen L. Edwards, James B. Leverenz, Thomas Montine, Brenna Cholerton, Kathleen L. Poston

Research output: Contribution to journalArticle

Abstract

Background: Clinicians and researchers commonly use global cognitive assessments to screen for impairment. Currently there are no published studies directly comparing the sensitivity and specificity of the Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 in PD. The objective of this study was to identify the relative sensitivity and specificity of the Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 in PD. Methods: The Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 were administered to training and validation cohorts. Cutoff scores were determined within the training cohort (n = 85) to optimize sensitivity and specificity for cognitive impairment and were applied to an independent validation cohort (n = 521). Results: The Montreal Cognitive Assessment was consistently sensitive across training and validation cohorts (90.0% and 80.3%, respectively), whereas the Mattis Dementia Rating Scale-2 was not (87.5% and 60.3%, respectively). In individual domains, the Montreal Cognitive Assessment remained sensitive to memory and visuospatial impairments (91.9% and 87.8%, respectively), whereas the Mattis Dementia Rating Scale-2 was sensitive to executive impairments (86.2%). Conclusion: The Montreal Cognitive Assessment and Mattis Dementia Rating Scale-2 demonstrated individual strengths. Future work should focus on developing domain-specific cognitive screening tools for PD.

Original languageEnglish (US)
JournalMovement Disorders
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Keywords

  • cognitive impairment
  • Mattis Dementia Rating Scale-2
  • Montreal Cognitive Assessment
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Hendershott, T. R., Zhu, D., Llanes, S., Zabetian, C. P., Quinn, J., Edwards, K. L., ... Poston, K. L. (Accepted/In press). Comparative sensitivity of the MoCA and Mattis Dementia Rating Scale-2 in Parkinson's disease. Movement Disorders. https://doi.org/10.1002/mds.27575