Comparative Pathology of Canine Soft Tissue Sarcomas: Possible Models of Human Non-rhabdomyosarcoma Soft Tissue Sarcomas

M. Milovancev, M. Hauck, C. Keller, L. W. Stranahan, Atiya Mansoor, D. E. Malarkey

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Comparative analyses of canine and human soft tissue sarcomas (STSs) are lacking. This study compared the histological and immunohistochemical (labelling for desmin, smooth muscle actin [SMA], CD31, pancytokeratin, S100 and CD34) appearance of 32 archived, formalin-fixed, paraffin wax-embedded canine STS tumour specimens by board-certified veterinary and medical pathologists, both blinded to the other's interpretations. Comparison between the veterinary and human diagnoses revealed a generally consistent pattern of interpretation with few notable variations. Most tumours (13/32) were judged to display similar histomorphological appearance to human low-grade spindle cell sarcomas, appearing non-distinctive and morphologically of a fibroblastic/myofibroblastic type. Five canine cases resembled human liposarcoma, but with atypical desmin-positive epithelioid cells present. Five canine cases resembled human spindle cell sarcoma with myxoid features and two additional cases resembled human myxofibrosarcoma. Seven canine cases were noted to resemble human undifferentiated sarcoma. Findings in the present study demonstrate that canine STSs display histological and immunohistochemical features similar to their human equivalents. Because of these cross-species similarities, a particular opportunity exists to understand the biology and treatment of human STS by potentially including dogs as clinical models.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalJournal of Comparative Pathology
Volume152
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

sarcoma
Sarcoma
Canidae
Pathology
dogs
desmin
Desmin
paraffin wax
tissues
Liposarcoma
Epithelioid Cells
neoplasms
Waxes
cells
formalin
Paraffin
smooth muscle
Formaldehyde
actin
Smooth Muscle

Keywords

  • Comparative pathology
  • Dog
  • Man
  • Soft tissue sarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)
  • Medicine(all)

Cite this

Comparative Pathology of Canine Soft Tissue Sarcomas : Possible Models of Human Non-rhabdomyosarcoma Soft Tissue Sarcomas. / Milovancev, M.; Hauck, M.; Keller, C.; Stranahan, L. W.; Mansoor, Atiya; Malarkey, D. E.

In: Journal of Comparative Pathology, Vol. 152, No. 1, 01.01.2015, p. 22-27.

Research output: Contribution to journalArticle

Milovancev, M. ; Hauck, M. ; Keller, C. ; Stranahan, L. W. ; Mansoor, Atiya ; Malarkey, D. E. / Comparative Pathology of Canine Soft Tissue Sarcomas : Possible Models of Human Non-rhabdomyosarcoma Soft Tissue Sarcomas. In: Journal of Comparative Pathology. 2015 ; Vol. 152, No. 1. pp. 22-27.
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