Comparative outcomes of radiofrequency ablation and cryoballoon ablation in dysplastic Barrett's esophagus: a propensity score−matched cohort study

Siddharth Agarwal, Mohammad Alshelleh, Jamie Scott, Lovekirat Dhaliwal, D. Chamil Codipilly, Ross Dierkhising, Cadman L. Leggett, Kenneth K. Wang, Fouad A. Otaki, Arvind J. Trindade, Prasad G. Iyer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background and Aims: Strong evidence supports the use of radiofrequency ablation (RFA) in the management of dysplastic/neoplastic Barrett's esophagus (BE). Recently, the efficacy of the cryoballoon ablation (CBA) system was demonstrated in multicenter cohort studies. We aimed to assess the comparative effectiveness and safety of these 2 ablation modalities for endoscopic eradication therapy (EET) in a cohort study. Methods: Data were abstracted on patients with dysplastic BE or intramucosal carcinoma undergoing EET using RFA or CBA as the primary ablation modality at 2 referral centers. The primary outcome was the rate of complete remission intestinal metaplasia (CRIM). Secondary outcomes were rates of complete remission of dysplasia (CRD) and adverse events. Cox proportional hazards models and propensity scored–matched analyses were conducted to compare outcomes. Results: Three hundred eleven patients (CBA, 85 patients; RFA, 226 patients) with a median follow-up of 1.5 years (interquartile range,.8, 2.5) in the RFA group and 2.0 years (interquartile range, 1.3, 2.5) in the CBA group were studied. On multivariable analyses, the chances of reaching CRD and CRIM were not influenced by ablation modality. Propensity score–matched analysis revealed a comparable chance of achieving CRIM (CBA vs RFA: hazard ratio, 1.24; 95% confidence interval,.79-1.96; P =.35) and CRD (CBA vs RFA: hazard ratio, 1.19; 95% confidence interval,.82-1.73; P =.36). The CBA group had a higher stricture rate compared with the RFA group (10.4% vs 4.4%, P =.04). Conclusions: Histologic outcomes of EET using CBA and RFA for dysplastic BE appear to be comparable. A randomized trial is needed to definitively compare outcomes between these 2 modalities.

Original languageEnglish (US)
Pages (from-to)422-431.e2
JournalGastrointestinal endoscopy
Volume95
Issue number3
DOIs
StatePublished - Mar 2022

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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