Comparative Metabolic Responses of Rat Kidney and Liver to Acute Doses of Fluoride

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Abstract

The metabolic responses of kidney and liver to acute doses of sodium fluoride were compared in the intact rat. In the liver, fluoride caused numerous changes in the concentrations of glycolytic and citric acid cycle intermediates indicating enzyme inhibition by fluoride. In the kidneys, fluoride caused no statistically significant changes in the concentrations of metabolic intermediates, except glucose. It is concluded that in the intact animal the kidney is more metabolically resistant to acute doses of fluoride than the liver. The author wishes to thank Mrs. Muriel Pallay and Mrs. Nadya Smejtek for expert technical assistance.

Original languageEnglish (US)
Pages (from-to)209-212
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume146
Issue number1
DOIs
StatePublished - May 1974

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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