Comparative genomic hybridization study of placental site trophoblastic tumour: A report of four cases

Pei Hui, Ali Riba, Tanja Pejovic, Tulin Johnson, Rebecca N. Baergen, David Ward

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Placental site trophoblastic tumour (PSTT) is a neoplastic proliferation of the implantation intermediate trophoblast. Although clinicopathological studies are not uncommon in case reports or small series, molecular and genetic studies are quite limited. Four archived cases of PSTT were successfully analysed by comparative genomic hybridization (CGH) in this study. Regional chromosomal gains were observed in two cases. One case showed chromosomal gains in the regions of 19p13.2, 21q11-21 and 22q12. The second case demonstrated a single regional chromosomal gain involving 21q21. No chromosomal loss is observed. The remaining two cases showed a balanced CGH profile without detectable chromosomal gain or loss. In summary, although chromosomal alterations detectable by CGH are not common, rare chromosomal gains do occur in PSTT. The recurrent chromosomal gain involving chromosomal 21q observed in two of our cases deserves additional studies to ascertain whether it carries any pathobiological significance.

Original languageEnglish (US)
Pages (from-to)248-251
Number of pages4
JournalModern Pathology
Volume17
Issue number2
DOIs
StatePublished - Feb 1 2004

Keywords

  • Comparative genomic hybridization
  • Placental site trophoblastic tumour

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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