Comparative effects of atenolol versus celiprolol on serum lipids and blood pressure in hyperlipidemic and hypertensive subjects

Carlos A. Dujovne, Jack Eff, Lawrence Ferraro, Robert J. Goldstein, Antonio M. Gotto, W. Dallas Hall, William Harris, S. Jolene Held, Alan Herd, Donald B. Hunninghake, Brian F. Johnson, Mario I. Sztern

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Antihypertensive drugs may affect serum lipoprotein levels in mixed populations but data in hyperlipidemic patients are scanty. Atenolol versus celiprolol effects on serum lipoproteins were compared in 159 hyperlipoproteinemic hypertensive patients. This was a randomized, double-blind, parallel-group, positive-controlled multicenter trial with centralized lipoprotein laboratory and diet constancy monitoring. Blood pressure reduction and serum lipoprotein and apoprotein levels were monitored for 3 months. Both drugs reduced systolic and diastolic blood pressures. Atenolol had greater effects than celiprolol on diastolic pressure, but effects on systolic blood pressure were not different. Patients receiving atenolol had lower serum high-density lipoprotein cholesterol levels and higher low-density lipoprotein/high-density lipoprotein cholesterol ratios, whereas patients treated with celiprolol showed no contrasting changes. These differences in lipoprotein levels between drug treatment groups were statistically significant at weeks 9 and 12. The difference between drug treatments was also significant if the values of the 9- and 12-week visits were averaged. Patients taking atenolol had statistically significantly higher serum levels of total cholesterol, triglycerides and apoprotein B at 9 weeks. These divergent directional changes were consistent throughout and statistically significantly different between drugs.

Original languageEnglish (US)
Pages (from-to)1131-1136
Number of pages6
JournalThe American Journal of Cardiology
Volume72
Issue number15
DOIs
StatePublished - Nov 15 1993
Externally publishedYes

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Celiprolol
Atenolol
Lipoproteins
Blood Pressure
Lipids
Serum
Pharmaceutical Preparations
HDL Cholesterol
Apoproteins
Apolipoproteins B
HDL Lipoproteins
LDL Lipoproteins
Antihypertensive Agents
Multicenter Studies
Triglycerides
Cholesterol
Diet
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comparative effects of atenolol versus celiprolol on serum lipids and blood pressure in hyperlipidemic and hypertensive subjects. / Dujovne, Carlos A.; Eff, Jack; Ferraro, Lawrence; Goldstein, Robert J.; Gotto, Antonio M.; Hall, W. Dallas; Harris, William; Held, S. Jolene; Herd, Alan; Hunninghake, Donald B.; Johnson, Brian F.; Sztern, Mario I.

In: The American Journal of Cardiology, Vol. 72, No. 15, 15.11.1993, p. 1131-1136.

Research output: Contribution to journalArticle

Dujovne, CA, Eff, J, Ferraro, L, Goldstein, RJ, Gotto, AM, Hall, WD, Harris, W, Held, SJ, Herd, A, Hunninghake, DB, Johnson, BF & Sztern, MI 1993, 'Comparative effects of atenolol versus celiprolol on serum lipids and blood pressure in hyperlipidemic and hypertensive subjects', The American Journal of Cardiology, vol. 72, no. 15, pp. 1131-1136. https://doi.org/10.1016/0002-9149(93)90981-H
Dujovne, Carlos A. ; Eff, Jack ; Ferraro, Lawrence ; Goldstein, Robert J. ; Gotto, Antonio M. ; Hall, W. Dallas ; Harris, William ; Held, S. Jolene ; Herd, Alan ; Hunninghake, Donald B. ; Johnson, Brian F. ; Sztern, Mario I. / Comparative effects of atenolol versus celiprolol on serum lipids and blood pressure in hyperlipidemic and hypertensive subjects. In: The American Journal of Cardiology. 1993 ; Vol. 72, No. 15. pp. 1131-1136.
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