Background: Various sampling techniques of the cervix have established false negative rates ranging from 18% to 45%. A number of studies suggest that this false negative rate can be reduced by sampling techniques that are associated with higher yields of endocervical cells. Method: This study enrolled 301 women, each of whom had a Pap smear obtained using three different sampling instruments (a cervical brush, a plastic spatula, and a cotton swab) in random order. Results: The cervical brush yielded a better endocervical sample than either of the other instruments (P<.001), and there was no difference between the swab and spatula. In addition, the recovery of endocervical cells increased with each additional sample taken, regardless of instrument used (P<.001), although the difference in yield between the second and third samples was not significant. Conclusions: To enhance the yield of endocervical cells in Pap smear sampling, consideration should be given to using the cervical brush routinely as a sampling instrument and to taking more than one sample per screening.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Jan 1 1993|
ASJC Scopus subject areas
- Family Practice