Comparative biodistribution and radioprotection studies with three radioprotective drugs in mouse tumors

J. S. Rasey, Kenneth Krohn, T. W. Menard, A. M. Spence

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The organ level biodistribution and tumor radioprotective properties of three drugs have been compared: WR-2721 (NSC 296961), WR-3689 (NSC 327729), and WR-77913 (NSC 318809). The three drugs have similar distribution patterns in normal mouse tissues. At 30 minutes after intraperitoneal injection, highest levels of 35S from radiolabeled protector are found in kidney and submandibular salivary gland, with lowest levels in brain and moderately low values in tumor and skin. Three of four tumors examined take up less WR-3689 than the other two protectors. For the three protectors, the dose modifying factors for the RIF-1 tumor irradiated in vivo and assayed in vitro are 1.5 - 1.7, but do not vary as predicted by differential uptake of drug into this neoplasm. In RIF-1, WR-3689 is taken up most avidly, but the three drugs tend to be equally protective.

Original languageEnglish (US)
Pages (from-to)1487-1490
Number of pages4
JournalInternational journal of radiation oncology, biology, physics
Volume12
Issue number8
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

S-2-(3-methylaminopropylamino)ethylphosphorothioic acid
Radiation-Protective Agents
protectors
mice
drugs
tumors
Amifostine
Neoplasms
Pharmaceutical Preparations
salivary glands
neoplasms
distribution (property)
kidneys
organs
Submandibular Gland
brain
Salivary Glands
Intraperitoneal Injections
injection
dosage

Keywords

  • C3HBA tumor
  • EMT-6 tumor
  • KHT tumor
  • Radioprotector
  • RIF-1 tumor
  • S-35 biodistribution
  • WR-2721
  • WR-3689
  • WR-77913

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Comparative biodistribution and radioprotection studies with three radioprotective drugs in mouse tumors. / Rasey, J. S.; Krohn, Kenneth; Menard, T. W.; Spence, A. M.

In: International journal of radiation oncology, biology, physics, Vol. 12, No. 8, 1986, p. 1487-1490.

Research output: Contribution to journalArticle

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abstract = "The organ level biodistribution and tumor radioprotective properties of three drugs have been compared: WR-2721 (NSC 296961), WR-3689 (NSC 327729), and WR-77913 (NSC 318809). The three drugs have similar distribution patterns in normal mouse tissues. At 30 minutes after intraperitoneal injection, highest levels of 35S from radiolabeled protector are found in kidney and submandibular salivary gland, with lowest levels in brain and moderately low values in tumor and skin. Three of four tumors examined take up less WR-3689 than the other two protectors. For the three protectors, the dose modifying factors for the RIF-1 tumor irradiated in vivo and assayed in vitro are 1.5 - 1.7, but do not vary as predicted by differential uptake of drug into this neoplasm. In RIF-1, WR-3689 is taken up most avidly, but the three drugs tend to be equally protective.",
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