Sequence variation in the gpl 16 component of cytomegalovirus envelope glycoprotein B was examined in 11 clinical strains and compared with variation in gp55. The peptide variation in gpl16 was found to be strongly clustered at codons 27-67, 44-460, and to a lesser extent at codons 181-194, 311-317, and 387-397. Strains adopted one of three to four peptide configurations at these loci, usually consistent with their gp55 sequence configuration. Two instances were observed of a sequence variation arising from recombination within gB. The limited, largely group-specific nature of variation in both gpl16 and gp55 facilitates functional and immunologic analyses.
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