Comparative Analysis of Outcome Following Liver Transplantation in US Veterans

Gregory L. Austin, Anna W. Sasaki, Atif Zaman, John M. Rabkin, Ali Olyaei, Roberta Ruimy, Susan L. Orloff, John Ham, Hugo R. Rosen

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The purpose of this study was to evaluate whether there was a difference in mortality following orthotopic liver transplantation (OLT) in a US veteran (VA) population (n = 149) compared to a non-VA (university) population (n = 285) and what factors could explain this difference. Survival following OLT for 149 VA patients was compared with that of 285 university patients. By Kaplan-Meier survival analysis, VA patients had higher mortality than university patients with respective 1-year, 3-year, and 5-year survival of 82%, 75%, and 68% vs. 87%, 82%, and 78% (p = 0.006). Gender, etiology of end-stage liver disease (ESLD) and donor age (i.e. older than 34 years) also significantly influenced survival. However, when donor and recipient age, gender, model for end-stage liver disease (MELD) score, and etiology of liver disease were included with hospital status in a multivariate Cox proportional hazards model, the VA population did not have higher mortality. A final model to predict mortality following transplantation was derived for all 434 patients where individuals were assigned risk scores based on the equation R = 0.219 (gender) + 0.018 (donor age) + 0.032 (recipient age) + 0.021 (MELD), where recipient age, donor age, and MELD score are the respective continuous variables and gender = 1 (men) and 0 for women (c-statistic = 0.71).

Original languageEnglish (US)
Pages (from-to)788-795
Number of pages8
JournalAmerican Journal of Transplantation
Volume4
Issue number5
DOIs
StatePublished - May 1 2004

Keywords

  • Hepatitis C
  • Liver transplantation
  • MELD (model for endstage liver disease)
  • Outcomes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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