TY - JOUR
T1 - Comparative Analysis of Outcome Following Liver Transplantation in US Veterans
AU - Austin, Gregory L.
AU - Sasaki, Anna W.
AU - Zaman, Atif
AU - Rabkin, John M.
AU - Olyaei, Ali
AU - Ruimy, Roberta
AU - Orloff, Susan L.
AU - Ham, John
AU - Rosen, Hugo R.
PY - 2004/5
Y1 - 2004/5
N2 - The purpose of this study was to evaluate whether there was a difference in mortality following orthotopic liver transplantation (OLT) in a US veteran (VA) population (n = 149) compared to a non-VA (university) population (n = 285) and what factors could explain this difference. Survival following OLT for 149 VA patients was compared with that of 285 university patients. By Kaplan-Meier survival analysis, VA patients had higher mortality than university patients with respective 1-year, 3-year, and 5-year survival of 82%, 75%, and 68% vs. 87%, 82%, and 78% (p = 0.006). Gender, etiology of end-stage liver disease (ESLD) and donor age (i.e. older than 34 years) also significantly influenced survival. However, when donor and recipient age, gender, model for end-stage liver disease (MELD) score, and etiology of liver disease were included with hospital status in a multivariate Cox proportional hazards model, the VA population did not have higher mortality. A final model to predict mortality following transplantation was derived for all 434 patients where individuals were assigned risk scores based on the equation R = 0.219 (gender) + 0.018 (donor age) + 0.032 (recipient age) + 0.021 (MELD), where recipient age, donor age, and MELD score are the respective continuous variables and gender = 1 (men) and 0 for women (c-statistic = 0.71).
AB - The purpose of this study was to evaluate whether there was a difference in mortality following orthotopic liver transplantation (OLT) in a US veteran (VA) population (n = 149) compared to a non-VA (university) population (n = 285) and what factors could explain this difference. Survival following OLT for 149 VA patients was compared with that of 285 university patients. By Kaplan-Meier survival analysis, VA patients had higher mortality than university patients with respective 1-year, 3-year, and 5-year survival of 82%, 75%, and 68% vs. 87%, 82%, and 78% (p = 0.006). Gender, etiology of end-stage liver disease (ESLD) and donor age (i.e. older than 34 years) also significantly influenced survival. However, when donor and recipient age, gender, model for end-stage liver disease (MELD) score, and etiology of liver disease were included with hospital status in a multivariate Cox proportional hazards model, the VA population did not have higher mortality. A final model to predict mortality following transplantation was derived for all 434 patients where individuals were assigned risk scores based on the equation R = 0.219 (gender) + 0.018 (donor age) + 0.032 (recipient age) + 0.021 (MELD), where recipient age, donor age, and MELD score are the respective continuous variables and gender = 1 (men) and 0 for women (c-statistic = 0.71).
KW - Hepatitis C
KW - Liver transplantation
KW - MELD (model for endstage liver disease)
KW - Outcomes
UR - http://www.scopus.com/inward/record.url?scp=2442598373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2442598373&partnerID=8YFLogxK
U2 - 10.1111/j.1600-6143.2004.00388.x
DO - 10.1111/j.1600-6143.2004.00388.x
M3 - Article
C2 - 15084176
AN - SCOPUS:2442598373
SN - 1600-6135
VL - 4
SP - 788
EP - 795
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 5
ER -