Comorbidity in Atopic Dermatitis

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

The negative impact of atopic dermatitis (AD) often extends beyond the skin. Children with AD experience increased rates of infectious, mental health, and allergic diseases compared to their non-atopic peers. The mechanisms underlying these associations remain elusive. New insights from genetic and epidermal research pinpoint the skin barrier as a primary initiator of AD. Epicutaneous sensitization represents an intriguing new model that links a disrupted skin barrier to the later development of IgE-mediated diseases in patients with AD. Recent epidemiologic studies have identified new comorbidities linked to AD as well, including several mental health disorders and obesity. This article reviews the recent literature regarding both classic and newly described AD comorbidities.

Original languageEnglish (US)
Pages (from-to)29-38
Number of pages10
JournalCurrent Dermatology Reports
Volume1
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Atopic Dermatitis
Comorbidity
Skin
Mental Health
Genetic Research
Mental Disorders
Immunoglobulin E
Epidemiologic Studies
Obesity

Keywords

  • Asthma
  • Atopic dermatitis
  • Attention-deficit-hyperactivity-disorder
  • Autism
  • Cancer
  • Comorbidity
  • Depression
  • Eczema
  • Epicutaneous sensitization
  • Food allergy
  • Skin barrier

ASJC Scopus subject areas

  • Dermatology

Cite this

Comorbidity in Atopic Dermatitis. / Simpson, Eric.

In: Current Dermatology Reports, Vol. 1, No. 1, 01.01.2012, p. 29-38.

Research output: Contribution to journalReview article

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