Common variants in CASQ2, GPD1L, and NOS1AP are significantly associated with risk of sudden death in patients with coronary artery disease

Shawn Westaway, Kyndaron Reinier, Adriana Huertas-Vazquez, Audrey Evanado, Carmen Teodorescu, Jo Navarro, Moritz F. Sinner, Karen Gunson, Jonathan Jui, Peter Spooner, Stefan Kaab, Sumeet S. Chugh

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background - Recent evidence suggests a genetic component for sudden cardiac death (SCD) in subjects with coronary artery disease (CAD). We conducted a systematic candidate-gene approach using haplotype-tagging single nucleotide polymorphisms (htSNPs) to identify genes associated with SCD risk in the context of CAD. Methods and Results - We investigated 1424 htSNPs representing 18 genes with mutations described in patients with ventricular arrhythmias in 291 subjects from the Oregon Sudden Unexpected Death Study (Ore-SUDS). The Ore-SUDS is an ongoing prospective investigation of SCD in the Portland, OR, metropolitan area (population, 1 000 000). SCD cases were ascertained from multiple sources and medical records were reviewed to determine the presence of CAD. A total of 36 SNPs were associated with risk of SCD (uncorrected probability values

Original languageEnglish (US)
Pages (from-to)397-402
Number of pages6
JournalCirculation: Cardiovascular Genetics
Volume4
Issue number4
DOIs
StatePublished - Aug 2011

Fingerprint

Sudden Cardiac Death
Sudden Death
Coronary Artery Disease
Single Nucleotide Polymorphism
Haplotypes
Genes
Medical Records
Cardiac Arrhythmias
Mutation
Population

Keywords

  • Death, sudden
  • Genomics
  • Risk prediction
  • Variants

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)
  • Genetics

Cite this

Common variants in CASQ2, GPD1L, and NOS1AP are significantly associated with risk of sudden death in patients with coronary artery disease. / Westaway, Shawn; Reinier, Kyndaron; Huertas-Vazquez, Adriana; Evanado, Audrey; Teodorescu, Carmen; Navarro, Jo; Sinner, Moritz F.; Gunson, Karen; Jui, Jonathan; Spooner, Peter; Kaab, Stefan; Chugh, Sumeet S.

In: Circulation: Cardiovascular Genetics, Vol. 4, No. 4, 08.2011, p. 397-402.

Research output: Contribution to journalArticle

Westaway, S, Reinier, K, Huertas-Vazquez, A, Evanado, A, Teodorescu, C, Navarro, J, Sinner, MF, Gunson, K, Jui, J, Spooner, P, Kaab, S & Chugh, SS 2011, 'Common variants in CASQ2, GPD1L, and NOS1AP are significantly associated with risk of sudden death in patients with coronary artery disease', Circulation: Cardiovascular Genetics, vol. 4, no. 4, pp. 397-402. https://doi.org/10.1161/CIRCGENETICS.111.959916
Westaway, Shawn ; Reinier, Kyndaron ; Huertas-Vazquez, Adriana ; Evanado, Audrey ; Teodorescu, Carmen ; Navarro, Jo ; Sinner, Moritz F. ; Gunson, Karen ; Jui, Jonathan ; Spooner, Peter ; Kaab, Stefan ; Chugh, Sumeet S. / Common variants in CASQ2, GPD1L, and NOS1AP are significantly associated with risk of sudden death in patients with coronary artery disease. In: Circulation: Cardiovascular Genetics. 2011 ; Vol. 4, No. 4. pp. 397-402.
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