Common variants in CASQ2, GPD1L, and NOS1AP are significantly associated with risk of sudden death in patients with coronary artery disease

K. Westaway Shawn, Kyndaron Reinier, Adriana Huertas-Vazquez, Audrey Evanado, Carmen Teodorescu, Jo Navarro, Moritz F. Sinner, Karen Gunson, Jonathan Jui, Peter Spooner, Stefan Kaab, Sumeet S. Chugh

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Background - Recent evidence suggests a genetic component for sudden cardiac death (SCD) in subjects with coronary artery disease (CAD). We conducted a systematic candidate-gene approach using haplotype-tagging single nucleotide polymorphisms (htSNPs) to identify genes associated with SCD risk in the context of CAD. Methods and Results - We investigated 1424 htSNPs representing 18 genes with mutations described in patients with ventricular arrhythmias in 291 subjects from the Oregon Sudden Unexpected Death Study (Ore-SUDS). The Ore-SUDS is an ongoing prospective investigation of SCD in the Portland, OR, metropolitan area (population, 1 000 000). SCD cases were ascertained from multiple sources and medical records were reviewed to determine the presence of CAD. A total of 36 SNPs were associated with risk of SCD (uncorrected probability values <0.01) in the initial study sample. These SNPs were subsequently tested for replication in an independent case-control study sample from the Ore-SUDS (n=688). The association analysis in the replication stage revealed 6 SNPs associated with SCD: CASQ2 region (rs17500488, P=0.04; rs3010396, P=0.007; rs7366407; P=0.04), NOS1AP (rs12084280, P=0.04; rs10918859, P=0.02), and 1 SNP located =26 kb upstream of GPD1L (rs9862154, P=0.04). Conclusions - Common variations in or near CASQ2, GPD1L, and NOS1AP are associated with increased risk of SCD in patients with CAD. These findings provide further evidence for overlap between the genetic architecture of rare and common forms of SCD, and replication in additional populations is warranted.

Original languageEnglish (US)
Pages (from-to)397-402
Number of pages6
JournalCirculation: Cardiovascular Genetics
Volume4
Issue number4
DOIs
StatePublished - Aug 1 2011

Keywords

  • Death, sudden
  • Genomics
  • Risk prediction
  • Variants

ASJC Scopus subject areas

  • Genetics
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Common variants in CASQ2, GPD1L, and NOS1AP are significantly associated with risk of sudden death in patients with coronary artery disease'. Together they form a unique fingerprint.

  • Cite this

    Shawn, K. W., Reinier, K., Huertas-Vazquez, A., Evanado, A., Teodorescu, C., Navarro, J., Sinner, M. F., Gunson, K., Jui, J., Spooner, P., Kaab, S., & Chugh, S. S. (2011). Common variants in CASQ2, GPD1L, and NOS1AP are significantly associated with risk of sudden death in patients with coronary artery disease. Circulation: Cardiovascular Genetics, 4(4), 397-402. https://doi.org/10.1161/CIRCGENETICS.111.959916