Common genetic variation in cellular transport genes and epithelial ovarian cancer (EOC) risk

AOCS management group

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk. Methods: In total, DNA samples were obtained from 14,525 case subjects with invasive EOC and from 23,447 controls from 43 sites in the Ovarian Cancer Association Consortium (OCAC). Two hundred seventy nine SNPs, representing 131 genes, were genotyped using an Illumina Infinium iSelect BeadChip as part of the Collaborative Oncological Gene-environment Study (COGS). SNP analyses were conducted using unconditional logistic regression under a log-additive model, and the FDR q-4). Conclusion: These results, generated on a large cohort of women, revealed associations between inherited cellular transport gene variants and risk of EOC histologic subtypes.

Original languageEnglish (US)
Article numbere0128106
JournalPLoS One
Volume10
Issue number6
DOIs
StatePublished - Jun 19 2015

Fingerprint

ovarian neoplasms
Genes
genetic variation
DNA Damage
Single Nucleotide Polymorphism
genes
DNA damage
DNA
Neoplasm Genes
Trace Elements
Regulator Genes
neoplasms
Ovarian Neoplasms
Reactive Oxygen Species
Iron
Logistic Models
Hormones
trace elements
Logistics
reactive oxygen species

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Common genetic variation in cellular transport genes and epithelial ovarian cancer (EOC) risk. / AOCS management group.

In: PLoS One, Vol. 10, No. 6, e0128106, 19.06.2015.

Research output: Contribution to journalArticle

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abstract = "Background: Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk. Methods: In total, DNA samples were obtained from 14,525 case subjects with invasive EOC and from 23,447 controls from 43 sites in the Ovarian Cancer Association Consortium (OCAC). Two hundred seventy nine SNPs, representing 131 genes, were genotyped using an Illumina Infinium iSelect BeadChip as part of the Collaborative Oncological Gene-environment Study (COGS). SNP analyses were conducted using unconditional logistic regression under a log-additive model, and the FDR q-4). Conclusion: These results, generated on a large cohort of women, revealed associations between inherited cellular transport gene variants and risk of EOC histologic subtypes.",
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AU - Chornokur, Ganna

AU - Lin, Hui Yi

AU - Tyrer, Jonathan P.

AU - Lawrenson, Kate

AU - Dennis, Joe

AU - Amankwah, Ernest K.

AU - Qu, Xiaotao

AU - Tsai, Ya Yu

AU - Jim, Heather S L

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AU - Bjorge, Line

AU - Bogdanova, Natalia

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AU - Brooks-Wilson, Angela

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AU - Fasching, Peter A.

AU - Fridley, Brooke L.

AU - Gao, Yu Tang

AU - Gentry-Maharaj, Aleksandra

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