Common genetic variants, acting additively, are a major source of risk for autism

Lambertus Klei, Stephan J. Sanders, Michael T. Murtha, Vanessa Hus, Jennifer K. Lowe, A. Jeremy Willsey, Daniel Moreno-De-Luca, Timothy W. Yu, Eric Fombonne, Daniel Geschwind, Dorothy E. Grice, David H. Ledbetter, Catherine Lord, Shrikant M. Mane, Christa Lese Martin, Donna M. Martin, Eric M. Morrow, Christopher A. Walsh, Nadine M. Melhem, Pauline ChasteJames S. Sutcliffe, Matthew W. State, Edwin H. Cook, Kathryn Roeder, Bernie Devlin

Research output: Contribution to journalArticle

239 Scopus citations

Abstract

Background: Autism spectrum disorders (ASD) are early onset neurodevelopmental syndromes typified by impairments in reciprocal social interaction and communication, accompanied by restricted and repetitive behaviors. While rare and especially de novo genetic variation are known to affect liability, whether common genetic polymorphism plays a substantial role is an open question and the relative contribution of genes and environment is contentious. It is probable that the relative contributions of rare and common variation, as well as environment, differs between ASD families having only a single affected individual (simplex) versus multiplex families who have two or more affected individuals. Methods. By using quantitative genetics techniques and the contrast of ASD subjects to controls, we estimate what portion of liability can be explained by additive genetic effects, known as narrow-sense heritability. We evaluate relatives of ASD subjects using the same methods to evaluate the assumptions of the additive model and partition families by simplex/multiplex status to determine how heritability changes with status. Results: By analyzing common variation throughout the genome, we show that common genetic polymorphism exerts substantial additive genetic effects on ASD liability and that simplex/multiplex family status has an impact on the identified composition of that risk. As a fraction of the total variation in liability, the estimated narrow-sense heritability exceeds 60% for ASD individuals from multiplex families and is approximately 40% for simplex families. By analyzing parents, unaffected siblings and alleles not transmitted from parents to their affected children, we conclude that the data for simplex ASD families follow the expectation for additive models closely. The data from multiplex families deviate somewhat from an additive model, possibly due to parental assortative mating. Conclusions: Our results, when viewed in the context of results from genome-wide association studies, demonstrate that a myriad of common variants of very small effect impacts ASD liability.

Original languageEnglish (US)
Article number9
JournalMolecular Autism
Volume3
Issue number1
DOIs
StatePublished - Dec 1 2012

Keywords

  • Multiplex
  • Narrow-sense heritability
  • Quantitative genetics
  • Simplex

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Neuroscience
  • Developmental Biology
  • Psychiatry and Mental health

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    Klei, L., Sanders, S. J., Murtha, M. T., Hus, V., Lowe, J. K., Willsey, A. J., Moreno-De-Luca, D., Yu, T. W., Fombonne, E., Geschwind, D., Grice, D. E., Ledbetter, D. H., Lord, C., Mane, S. M., Martin, C. L., Martin, D. M., Morrow, E. M., Walsh, C. A., Melhem, N. M., ... Devlin, B. (2012). Common genetic variants, acting additively, are a major source of risk for autism. Molecular Autism, 3(1), [9]. https://doi.org/10.1186/2040-2392-3-9