Abstract
Many diseases of the nervous system cause dysfunction by impairing neuronal physiology more than by altering brain anatomy - including age-related cognitive decline, most psychiatric disorders, and even the earliest stages of Alzheimer's disease. The absence of clear anatomical markers makes it difficult to identify targeted cells, which in turn impedes attempts to isolate the pathogenic molecules that cause physiologic disruption. Here we show how brain imaging and microarray can be used as complimentary techniques that together can characterize the cellular and molecular aspects of this class of diseases.
Original language | English (US) |
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Pages (from-to) | 1145-1152 |
Number of pages | 8 |
Journal | Neurochemical Research |
Volume | 29 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2004 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Brain anatomy
- Neuronal physiology
- Pathogenic molecules
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience