Combining brain imaging with microarray: Isolating molecules underlying the physiologic disorders of the brain

Aimee Pierce, Scott A. Small

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Many diseases of the nervous system cause dysfunction by impairing neuronal physiology more than by altering brain anatomy - including age-related cognitive decline, most psychiatric disorders, and even the earliest stages of Alzheimer's disease. The absence of clear anatomical markers makes it difficult to identify targeted cells, which in turn impedes attempts to isolate the pathogenic molecules that cause physiologic disruption. Here we show how brain imaging and microarray can be used as complimentary techniques that together can characterize the cellular and molecular aspects of this class of diseases.

Original languageEnglish (US)
Pages (from-to)1145-1152
Number of pages8
JournalNeurochemical Research
Volume29
Issue number6
DOIs
StatePublished - Jun 1 2004

Keywords

  • Alzheimer's disease
  • Brain anatomy
  • Neuronal physiology
  • Pathogenic molecules

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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