Combined intraarterial chemotherapy, radiation therapy, and surgery for advanced squamous-cell carcinoma of the head and neck

B. C. Zielke-Temme, Kenneth Stevens, E. C. Everts, H. S. Moseley, K. M. Ireland

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

From 1973 to 1978, 20 patients with T3 and T4 squamous cell carcinoma of the head and neck were treated according to triple-therapy protocol at the University of Oregon Health Sciences Center. Intraarterial chemotherapy (IAC) with bleomycin and methotrexate was given prior to high-dose preoperative radiation therapy and then, when possible, the lesion was resected. The treatment results are presented. The initial clinical response to IAC and radiation correlated well with the findings in the pathologic examination of the resected specimen in 11 patients, but it did not correlate well with the subsequent clinical course of the patient. In view of the results of this pilot study, we do not feel that it is justified to continue IAC with bleomycin and methotrexate prior to conventional therapy in the very advanced and aggressive cancers of the head and neck. However, IAC might be justified in treating patients with operable Stage III carcinomas of the maxillary antrum.

Original languageEnglish (US)
Pages (from-to)1527-1532
Number of pages6
JournalCancer
Volume45
Issue number7
StatePublished - 1980

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Radiotherapy
Drug Therapy
Bleomycin
Methotrexate
CD4-Positive T-Lymphocytes
Maxillary Sinus
Head and Neck Neoplasms
Therapeutics
Radiation
Carcinoma
Carcinoma, squamous cell of head and neck
Health

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Zielke-Temme, B. C., Stevens, K., Everts, E. C., Moseley, H. S., & Ireland, K. M. (1980). Combined intraarterial chemotherapy, radiation therapy, and surgery for advanced squamous-cell carcinoma of the head and neck. Cancer, 45(7), 1527-1532.

Combined intraarterial chemotherapy, radiation therapy, and surgery for advanced squamous-cell carcinoma of the head and neck. / Zielke-Temme, B. C.; Stevens, Kenneth; Everts, E. C.; Moseley, H. S.; Ireland, K. M.

In: Cancer, Vol. 45, No. 7, 1980, p. 1527-1532.

Research output: Contribution to journalArticle

Zielke-Temme, BC, Stevens, K, Everts, EC, Moseley, HS & Ireland, KM 1980, 'Combined intraarterial chemotherapy, radiation therapy, and surgery for advanced squamous-cell carcinoma of the head and neck', Cancer, vol. 45, no. 7, pp. 1527-1532.
Zielke-Temme BC, Stevens K, Everts EC, Moseley HS, Ireland KM. Combined intraarterial chemotherapy, radiation therapy, and surgery for advanced squamous-cell carcinoma of the head and neck. Cancer. 1980;45(7):1527-1532.
Zielke-Temme, B. C. ; Stevens, Kenneth ; Everts, E. C. ; Moseley, H. S. ; Ireland, K. M. / Combined intraarterial chemotherapy, radiation therapy, and surgery for advanced squamous-cell carcinoma of the head and neck. In: Cancer. 1980 ; Vol. 45, No. 7. pp. 1527-1532.
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