TY - JOUR
T1 - Combined and sequential effects of alcohol and methamphetamine in animal models
AU - Stafford, Alexandra M.
AU - Yamamoto, Bryan K.
AU - Phillips, Tamara J.
N1 - Funding Information:
Funding was provided by NIAAA T32AA07468 (AMS), NCATS TL1TR002371 (AMS), NIDA R01DA042737 (BKY), NIAAA P60AA010760 (TJP), NIAAA R24AA020245 (TJP), NIDA P50DA018165 (TJP), NIDA U01DA041579 (TJP), NIDA R01DA046081 (TJP), Department of Veterans Affairs Merit Review Grant I01BX002106 (TJP), and the VA Senior Research Career Scientist Program (TJP). The contents of this article do not represent the views of the U.S. Department of Veterans Affairs or the United States government.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/12
Y1 - 2021/12
N2 - Comorbid drug use, often alcohol with other drugs, poses significant health and societal concerns. Methamphetamine is among the illicit drugs most often co-used with alcohol. The current review examines the animal literature for impacts of comorbid alcohol and methamphetamine exposure. We found evidence for additive or synergistic effects of combined or sequential exposure on behavior and physiology. Dopaminergic, serotonergic, and glutamatergic systems are all impacted by combined exposure to alcohol and methamphetamine and cyclooxygenase-2 activity plays an important role in their combined neurotoxic effects. Adverse consequences of comorbid exposure include altered brain development with prenatal exposure, impaired learning and memory, motor deficits, gastrotoxicity, hepatotoxicity, and augmented intake under some conditions. Given high susceptibility to drug experimentation in adolescence, studies of co-exposure during the adolescent period and of how adolescent exposure to one drug impacts later use or sensitivity to the other drug should be a priority. Further, to gain traction on prevention and treatment, additional research to identify motivational and neurobiological drivers and consequences of comorbid use is needed.
AB - Comorbid drug use, often alcohol with other drugs, poses significant health and societal concerns. Methamphetamine is among the illicit drugs most often co-used with alcohol. The current review examines the animal literature for impacts of comorbid alcohol and methamphetamine exposure. We found evidence for additive or synergistic effects of combined or sequential exposure on behavior and physiology. Dopaminergic, serotonergic, and glutamatergic systems are all impacted by combined exposure to alcohol and methamphetamine and cyclooxygenase-2 activity plays an important role in their combined neurotoxic effects. Adverse consequences of comorbid exposure include altered brain development with prenatal exposure, impaired learning and memory, motor deficits, gastrotoxicity, hepatotoxicity, and augmented intake under some conditions. Given high susceptibility to drug experimentation in adolescence, studies of co-exposure during the adolescent period and of how adolescent exposure to one drug impacts later use or sensitivity to the other drug should be a priority. Further, to gain traction on prevention and treatment, additional research to identify motivational and neurobiological drivers and consequences of comorbid use is needed.
KW - Addiction
KW - Alcohol use disorder
KW - Amphetamine
KW - Comorbid drug use
KW - Ethanol
KW - Neurotoxicity
KW - Substance use disorder
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U2 - 10.1016/j.neubiorev.2021.09.019
DO - 10.1016/j.neubiorev.2021.09.019
M3 - Review article
C2 - 34543650
AN - SCOPUS:85115759354
VL - 131
SP - 248
EP - 269
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
ER -