Colorectal cancer in young patients: Characteristics and outcome

P. Y. Lee, W. S. Fletcher, E. S. Sullivan, J. T. Vetto

    Research output: Contribution to journalArticle

    80 Scopus citations

    Abstract

    Controversy still exists regarding the features and prognosis of colorectal cancer in young patients. We reviewed the records of 62 patients 40 years of age and younger with adenocarcinoma of the colon and rectum, treated and followed at our institution between 1968 and 1991. These patients represented 3.1 per cent of our total colorectal patient population during that time period. Their mean age was 34.5 years old, with the youngest patient being 18 years of age. Modified Dukes stages at presentation were 8 per cent A, 20 per cent B, 23 per cent C, and 48 per cent D. Underlying inflammatory bowel disease was present in 21 per cent of patients and was proportionately distributed between high (C and D) and low (A and B) stages. Half of the stage D patients had high grade lesions, compared with only 20 per cent of lower stage patients (P = 0.037). All but two patients had operative exploration; 36 (60%) had complete resection of all gross disease. With a mean follow-up of 98.2 months, the 5-year overall survival for stage A disease was 100 per cent, but dropped to 85, 40, and 7 per cent for stages B, C and D, respectively. Compared to published figures for the general population, younger patients with colon and rectal cancer tend to present at a more advanced stage, but have similar stage-related survival.

    Original languageEnglish (US)
    Pages (from-to)607-612
    Number of pages6
    JournalAmerican Surgeon
    Volume60
    Issue number8
    StatePublished - Jan 1 1994

    ASJC Scopus subject areas

    • Surgery

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    Lee, P. Y., Fletcher, W. S., Sullivan, E. S., & Vetto, J. T. (1994). Colorectal cancer in young patients: Characteristics and outcome. American Surgeon, 60(8), 607-612.