Colorectal cancer

Ernst J. Kuipers, William M. Grady, David Lieberman, Thomas Seufferlein, Joseph J. Sung, Petra G. Boelens, Cornelis J.H. Van De Velde, Toshiaki Watanabe

Research output: Contribution to journalArticle

225 Citations (Scopus)

Abstract

Colorectal cancer had a low incidence several decades ago. However, it has become a predominant cancer and now accounts for approximately 10% of cancer-related mortality in western countries. The 'rise' of colorectal cancer in developed countries can be attributed to the increasingly ageing population, unfavourable modern dietary habits and an increase in risk factors, such as smoking, low physical exercise and obesity. New treatments for primary and metastatic colorectal cancer have emerged, providing additional options for patients; these treatments include laparoscopic surgery for primary disease, more-aggressive resection of metastatic disease (such as liver and pulmonary metastases), radiotherapy for rectal cancer, and neoadjuvant and palliative chemotherapies. However, these new treatment options have had limited impact on cure rates and long-term survival. For these reasons, and the recognition that colorectal cancer is long preceded by a polypoid precursor, screening programmes have gained momentum. This Primer provides an overview of the current state of the art of knowledge on the epidemiology and mechanisms of colorectal cancer, as well as on diagnosis and treatment.

Original languageEnglish (US)
Article number15065
JournalNature Reviews Disease Primers
Volume1
DOIs
StatePublished - Nov 5 2015

Fingerprint

Colorectal Neoplasms
Feeding Behavior
Therapeutics
Rectal Neoplasms
Developed Countries
Laparoscopy
Neoplasms
Epidemiology
Radiotherapy
Obesity
Smoking
Exercise
Neoplasm Metastasis
Drug Therapy
Lung
Survival
Mortality
Liver
Incidence
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kuipers, E. J., Grady, W. M., Lieberman, D., Seufferlein, T., Sung, J. J., Boelens, P. G., ... Watanabe, T. (2015). Colorectal cancer. Nature Reviews Disease Primers, 1, [15065]. https://doi.org/10.1038/nrdp.2015.65

Colorectal cancer. / Kuipers, Ernst J.; Grady, William M.; Lieberman, David; Seufferlein, Thomas; Sung, Joseph J.; Boelens, Petra G.; Van De Velde, Cornelis J.H.; Watanabe, Toshiaki.

In: Nature Reviews Disease Primers, Vol. 1, 15065, 05.11.2015.

Research output: Contribution to journalArticle

Kuipers, EJ, Grady, WM, Lieberman, D, Seufferlein, T, Sung, JJ, Boelens, PG, Van De Velde, CJH & Watanabe, T 2015, 'Colorectal cancer', Nature Reviews Disease Primers, vol. 1, 15065. https://doi.org/10.1038/nrdp.2015.65
Kuipers EJ, Grady WM, Lieberman D, Seufferlein T, Sung JJ, Boelens PG et al. Colorectal cancer. Nature Reviews Disease Primers. 2015 Nov 5;1. 15065. https://doi.org/10.1038/nrdp.2015.65
Kuipers, Ernst J. ; Grady, William M. ; Lieberman, David ; Seufferlein, Thomas ; Sung, Joseph J. ; Boelens, Petra G. ; Van De Velde, Cornelis J.H. ; Watanabe, Toshiaki. / Colorectal cancer. In: Nature Reviews Disease Primers. 2015 ; Vol. 1.
@article{a604c59d70944c658c00f9eeae80e3b6,
title = "Colorectal cancer",
abstract = "Colorectal cancer had a low incidence several decades ago. However, it has become a predominant cancer and now accounts for approximately 10{\%} of cancer-related mortality in western countries. The 'rise' of colorectal cancer in developed countries can be attributed to the increasingly ageing population, unfavourable modern dietary habits and an increase in risk factors, such as smoking, low physical exercise and obesity. New treatments for primary and metastatic colorectal cancer have emerged, providing additional options for patients; these treatments include laparoscopic surgery for primary disease, more-aggressive resection of metastatic disease (such as liver and pulmonary metastases), radiotherapy for rectal cancer, and neoadjuvant and palliative chemotherapies. However, these new treatment options have had limited impact on cure rates and long-term survival. For these reasons, and the recognition that colorectal cancer is long preceded by a polypoid precursor, screening programmes have gained momentum. This Primer provides an overview of the current state of the art of knowledge on the epidemiology and mechanisms of colorectal cancer, as well as on diagnosis and treatment.",
author = "Kuipers, {Ernst J.} and Grady, {William M.} and David Lieberman and Thomas Seufferlein and Sung, {Joseph J.} and Boelens, {Petra G.} and {Van De Velde}, {Cornelis J.H.} and Toshiaki Watanabe",
year = "2015",
month = "11",
day = "5",
doi = "10.1038/nrdp.2015.65",
language = "English (US)",
volume = "1",
journal = "Nature Reviews Disease Primers",
issn = "2056-676X",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Colorectal cancer

AU - Kuipers, Ernst J.

AU - Grady, William M.

AU - Lieberman, David

AU - Seufferlein, Thomas

AU - Sung, Joseph J.

AU - Boelens, Petra G.

AU - Van De Velde, Cornelis J.H.

AU - Watanabe, Toshiaki

PY - 2015/11/5

Y1 - 2015/11/5

N2 - Colorectal cancer had a low incidence several decades ago. However, it has become a predominant cancer and now accounts for approximately 10% of cancer-related mortality in western countries. The 'rise' of colorectal cancer in developed countries can be attributed to the increasingly ageing population, unfavourable modern dietary habits and an increase in risk factors, such as smoking, low physical exercise and obesity. New treatments for primary and metastatic colorectal cancer have emerged, providing additional options for patients; these treatments include laparoscopic surgery for primary disease, more-aggressive resection of metastatic disease (such as liver and pulmonary metastases), radiotherapy for rectal cancer, and neoadjuvant and palliative chemotherapies. However, these new treatment options have had limited impact on cure rates and long-term survival. For these reasons, and the recognition that colorectal cancer is long preceded by a polypoid precursor, screening programmes have gained momentum. This Primer provides an overview of the current state of the art of knowledge on the epidemiology and mechanisms of colorectal cancer, as well as on diagnosis and treatment.

AB - Colorectal cancer had a low incidence several decades ago. However, it has become a predominant cancer and now accounts for approximately 10% of cancer-related mortality in western countries. The 'rise' of colorectal cancer in developed countries can be attributed to the increasingly ageing population, unfavourable modern dietary habits and an increase in risk factors, such as smoking, low physical exercise and obesity. New treatments for primary and metastatic colorectal cancer have emerged, providing additional options for patients; these treatments include laparoscopic surgery for primary disease, more-aggressive resection of metastatic disease (such as liver and pulmonary metastases), radiotherapy for rectal cancer, and neoadjuvant and palliative chemotherapies. However, these new treatment options have had limited impact on cure rates and long-term survival. For these reasons, and the recognition that colorectal cancer is long preceded by a polypoid precursor, screening programmes have gained momentum. This Primer provides an overview of the current state of the art of knowledge on the epidemiology and mechanisms of colorectal cancer, as well as on diagnosis and treatment.

UR - http://www.scopus.com/inward/record.url?scp=85016401916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016401916&partnerID=8YFLogxK

U2 - 10.1038/nrdp.2015.65

DO - 10.1038/nrdp.2015.65

M3 - Article

C2 - 27189416

AN - SCOPUS:85016401916

VL - 1

JO - Nature Reviews Disease Primers

JF - Nature Reviews Disease Primers

SN - 2056-676X

M1 - 15065

ER -