Collagen deposition limits immune reconstitution in the gut

Jacob Estes, Jason V. Baker, Jason M. Brenchley, Alex Khoruts, Jacob L. Barthold, Anne Bantle, Cavan S. Reilly, Gregory J. Beilman, Mark E. George, Daniel C. Douek, Ashley T. Haase, Timothy W. Schacker

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Despite suppression of human immunodeficiency virus (HIV) replication by antiretroviral therapy, reconstitution of CD4+ cells is variable and incomplete, particularly in gut-associated lymphatic tissues (GALT). We have previously shown that immune activation and inflammation in HIV-infected and simian immunodeficiency virus-infected lymph nodes results in collagen deposition and disruption of the lymphatic tissue architecture, and this damage contributes to CD4+ cell depletion before treatment and affects the extent of immune reconstitution after treatment. In the present study, we compared collagen deposition and the extent of depletion and reconstitution of total CD4+ cells and subsets in peripheral blood, lymph nodes, and inductive and effector sites in GALT. We show that CD4+ cell depletion in GALT correlates with the rapidity and greater magnitude of collagen deposition in this compartment, compared with that in peripheral lymph nodes, and that although treatment does not restore CD4+ cells to effector sites, treatment in the early stages of infection can increase CD4+ central memory cells in Peyer patches.

Original languageEnglish (US)
Pages (from-to)456-464
Number of pages9
JournalJournal of Infectious Diseases
Volume198
Issue number4
DOIs
StatePublished - Aug 15 2008
Externally publishedYes

Fingerprint

Collagen
Lymphoid Tissue
Lymph Nodes
HIV
Peyer's Patches
Simian Immunodeficiency Virus
Virus Replication
Inflammation
Infection
Therapeutics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Estes, J., Baker, J. V., Brenchley, J. M., Khoruts, A., Barthold, J. L., Bantle, A., ... Schacker, T. W. (2008). Collagen deposition limits immune reconstitution in the gut. Journal of Infectious Diseases, 198(4), 456-464. https://doi.org/10.1086/590112

Collagen deposition limits immune reconstitution in the gut. / Estes, Jacob; Baker, Jason V.; Brenchley, Jason M.; Khoruts, Alex; Barthold, Jacob L.; Bantle, Anne; Reilly, Cavan S.; Beilman, Gregory J.; George, Mark E.; Douek, Daniel C.; Haase, Ashley T.; Schacker, Timothy W.

In: Journal of Infectious Diseases, Vol. 198, No. 4, 15.08.2008, p. 456-464.

Research output: Contribution to journalArticle

Estes, J, Baker, JV, Brenchley, JM, Khoruts, A, Barthold, JL, Bantle, A, Reilly, CS, Beilman, GJ, George, ME, Douek, DC, Haase, AT & Schacker, TW 2008, 'Collagen deposition limits immune reconstitution in the gut', Journal of Infectious Diseases, vol. 198, no. 4, pp. 456-464. https://doi.org/10.1086/590112
Estes J, Baker JV, Brenchley JM, Khoruts A, Barthold JL, Bantle A et al. Collagen deposition limits immune reconstitution in the gut. Journal of Infectious Diseases. 2008 Aug 15;198(4):456-464. https://doi.org/10.1086/590112
Estes, Jacob ; Baker, Jason V. ; Brenchley, Jason M. ; Khoruts, Alex ; Barthold, Jacob L. ; Bantle, Anne ; Reilly, Cavan S. ; Beilman, Gregory J. ; George, Mark E. ; Douek, Daniel C. ; Haase, Ashley T. ; Schacker, Timothy W. / Collagen deposition limits immune reconstitution in the gut. In: Journal of Infectious Diseases. 2008 ; Vol. 198, No. 4. pp. 456-464.
@article{6dc17d9d1d1447b4927d96808498a502,
title = "Collagen deposition limits immune reconstitution in the gut",
abstract = "Despite suppression of human immunodeficiency virus (HIV) replication by antiretroviral therapy, reconstitution of CD4+ cells is variable and incomplete, particularly in gut-associated lymphatic tissues (GALT). We have previously shown that immune activation and inflammation in HIV-infected and simian immunodeficiency virus-infected lymph nodes results in collagen deposition and disruption of the lymphatic tissue architecture, and this damage contributes to CD4+ cell depletion before treatment and affects the extent of immune reconstitution after treatment. In the present study, we compared collagen deposition and the extent of depletion and reconstitution of total CD4+ cells and subsets in peripheral blood, lymph nodes, and inductive and effector sites in GALT. We show that CD4+ cell depletion in GALT correlates with the rapidity and greater magnitude of collagen deposition in this compartment, compared with that in peripheral lymph nodes, and that although treatment does not restore CD4+ cells to effector sites, treatment in the early stages of infection can increase CD4+ central memory cells in Peyer patches.",
author = "Jacob Estes and Baker, {Jason V.} and Brenchley, {Jason M.} and Alex Khoruts and Barthold, {Jacob L.} and Anne Bantle and Reilly, {Cavan S.} and Beilman, {Gregory J.} and George, {Mark E.} and Douek, {Daniel C.} and Haase, {Ashley T.} and Schacker, {Timothy W.}",
year = "2008",
month = "8",
day = "15",
doi = "10.1086/590112",
language = "English (US)",
volume = "198",
pages = "456--464",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Collagen deposition limits immune reconstitution in the gut

AU - Estes, Jacob

AU - Baker, Jason V.

AU - Brenchley, Jason M.

AU - Khoruts, Alex

AU - Barthold, Jacob L.

AU - Bantle, Anne

AU - Reilly, Cavan S.

AU - Beilman, Gregory J.

AU - George, Mark E.

AU - Douek, Daniel C.

AU - Haase, Ashley T.

AU - Schacker, Timothy W.

PY - 2008/8/15

Y1 - 2008/8/15

N2 - Despite suppression of human immunodeficiency virus (HIV) replication by antiretroviral therapy, reconstitution of CD4+ cells is variable and incomplete, particularly in gut-associated lymphatic tissues (GALT). We have previously shown that immune activation and inflammation in HIV-infected and simian immunodeficiency virus-infected lymph nodes results in collagen deposition and disruption of the lymphatic tissue architecture, and this damage contributes to CD4+ cell depletion before treatment and affects the extent of immune reconstitution after treatment. In the present study, we compared collagen deposition and the extent of depletion and reconstitution of total CD4+ cells and subsets in peripheral blood, lymph nodes, and inductive and effector sites in GALT. We show that CD4+ cell depletion in GALT correlates with the rapidity and greater magnitude of collagen deposition in this compartment, compared with that in peripheral lymph nodes, and that although treatment does not restore CD4+ cells to effector sites, treatment in the early stages of infection can increase CD4+ central memory cells in Peyer patches.

AB - Despite suppression of human immunodeficiency virus (HIV) replication by antiretroviral therapy, reconstitution of CD4+ cells is variable and incomplete, particularly in gut-associated lymphatic tissues (GALT). We have previously shown that immune activation and inflammation in HIV-infected and simian immunodeficiency virus-infected lymph nodes results in collagen deposition and disruption of the lymphatic tissue architecture, and this damage contributes to CD4+ cell depletion before treatment and affects the extent of immune reconstitution after treatment. In the present study, we compared collagen deposition and the extent of depletion and reconstitution of total CD4+ cells and subsets in peripheral blood, lymph nodes, and inductive and effector sites in GALT. We show that CD4+ cell depletion in GALT correlates with the rapidity and greater magnitude of collagen deposition in this compartment, compared with that in peripheral lymph nodes, and that although treatment does not restore CD4+ cells to effector sites, treatment in the early stages of infection can increase CD4+ central memory cells in Peyer patches.

UR - http://www.scopus.com/inward/record.url?scp=48749093073&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48749093073&partnerID=8YFLogxK

U2 - 10.1086/590112

DO - 10.1086/590112

M3 - Article

C2 - 18598193

AN - SCOPUS:48749093073

VL - 198

SP - 456

EP - 464

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 4

ER -