Cold hard facts of cryoglobulinemia. Updates on clinical features and treatment advances

Elena (Daniela) Ghetie, Navid Mehraban, Cailin Sibley

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Cryoglobulins are immunoglobulins that precipitate at temperatures less than 37°C. They occur secondary to infectious, autoimmune, and malignant processes. In the Brouet classification, type I cryoglobulinemia is caused by hyperviscosity, whereas type II and III manifestations are caused by vasculitis in target organs (primarily skin, peripheral nerves, and kidney). New classification criteria were recently proposed that may help with study and treatment of cryoglobulinemic vasculitis (CryoVas). Hepatitis C virus is the most common cause of CryoVas and treatment with antivirals can be curative in mild cases, whereas rituximab is highly effective in treating active vasculitis in more severe cases.

Original languageEnglish (US)
Pages (from-to)93-108
Number of pages16
JournalRheumatic Disease Clinics of North America
Volume41
Issue number1
DOIs
StatePublished - Feb 1 2015

Fingerprint

Cryoglobulinemia
Vasculitis
Cryoglobulins
Peripheral Nerves
Hepacivirus
Antiviral Agents
Immunoglobulins
Kidney
Skin
Temperature

Keywords

  • Cryoglobulinemia
  • Cryoglobulinemic
  • Diagnosis
  • HCV
  • Rituximab
  • Treatment
  • Vasculitis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Cold hard facts of cryoglobulinemia. Updates on clinical features and treatment advances. / Ghetie, Elena (Daniela); Mehraban, Navid; Sibley, Cailin.

In: Rheumatic Disease Clinics of North America, Vol. 41, No. 1, 01.02.2015, p. 93-108.

Research output: Contribution to journalArticle

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