Col2-GFP reporter mouse - A new tool to study skeletal development

Jae Y. Cho, T. Dawn Grant, Gregory P. Lunstrum, William A. Horton

Research output: Contribution to journalShort surveypeer-review

13 Scopus citations

Abstract

Transgenic mice were generated that harbor a Col2-GFP reporter that marks chondrocytes and their immediate precursors during skeletal development. Cells engaged in chondrogenesis were identified by conventional fluorescence microscopy and confocal optical sectioning within their native environments in live embryos and in thick tissue slices. The use of these mice offers a novel approach for studying the role of chondrocytes in skeletal development.

Original languageEnglish (US)
Pages (from-to)251-253
Number of pages3
JournalAmerican Journal of Medical Genetics - Seminars in Medical Genetics
Volume106
Issue number4
DOIs
StatePublished - Dec 1 2001
Externally publishedYes

Keywords

  • Chondrocytes
  • Chondrogenesis
  • Confocal microscopy
  • Green fluorescent protein
  • Reporter mice
  • Skeletal development
  • Transgenic mice
  • Type II collagen

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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