Cohesin Is Out for Stalled Replication Fork Restart

Sebnem Ece Eksi, Joshua C. Saldivar

Research output: Contribution to journalArticlepeer-review

Abstract

Replication stress underlies many genomic alterations in cancer cells. In this issue of Developmental Cell, Benedict et al. show that WAPL-dependent cohesin removal is needed to restart DNA synthesis at stalled forks and promote survival following replication stress, uncovering an unexpected link between stress and sister chromatid cohesion loss.

Original languageEnglish (US)
Pages (from-to)675-676
Number of pages2
JournalDevelopmental Cell
Volume52
Issue number6
DOIs
StatePublished - Mar 23 2020

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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