Cognitive functions in primary central nervous system lymphoma: Literature review and assessment guidelines

D. D. Correa, L. Maron, H. Harder, M. Klein, C. L. Armstrong, P. Calabrese, J. E.C. Bromberg, L. E. Abrey, T. T. Batchelor, D. Schiff

Research output: Contribution to journalReview articlepeer-review

137 Scopus citations


Background: Treatment-related neurotoxicity has been recognized as a significant problem in patients with primary central nervous system lymphoma (PCNSL) as effective treatment has increased survival rates. There is, however, a paucity of research on cognitive functions in this population. Design: In a review of the literature, a total of 17 articles that described cognitive outcome in adult PCNSL patients were identified. Results: The studies that assessed cognitive functions after whole-brain radiotherapy combined with chemotherapy reported cognitive impairment in most patients. Patients treated with chemotherapy alone had either stable or improved cognitive performance in most studies. Methodological problems, however, limited the ability to ascertain the specific contribution of disease and various treatment interventions to cognitive outcome. On the basis of the literature review, a battery of cognitive and quality-of-life (QoL) measures to be used in prospective clinical trials was proposed. The battery is composed of five standardized neuropsychological tests, covering four domains sensitive to disease and treatment effects (attention, executive functions, memory, psychomotor speed), and QoL questionnaires, and meets criteria for use in collaborative trials. Conclusion: The incorporation of formal and systematic cognitive evaluations in PCNSL studies will improve our understanding of treatment-related neurotoxicity in this population.

Original languageEnglish (US)
Pages (from-to)1145-1151
Number of pages7
JournalAnnals of Oncology
Issue number7
StatePublished - Jul 2007


  • Chemotherapy
  • Cognitive
  • Neurotoxicity
  • Primary CNS lymphoma
  • Radiotherapy

ASJC Scopus subject areas

  • Hematology
  • Oncology


Dive into the research topics of 'Cognitive functions in primary central nervous system lymphoma: Literature review and assessment guidelines'. Together they form a unique fingerprint.

Cite this