Cognitive functions in primary central nervous system lymphoma

Literature review and assessment guidelines

D. D. Correa, Leeza Maron, H. Harder, M. Klein, C. L. Armstrong, P. Calabrese, J. E C Bromberg, L. E. Abrey, T. T. Batchelor, D. Schiff

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Background: Treatment-related neurotoxicity has been recognized as a significant problem in patients with primary central nervous system lymphoma (PCNSL) as effective treatment has increased survival rates. There is, however, a paucity of research on cognitive functions in this population. Design: In a review of the literature, a total of 17 articles that described cognitive outcome in adult PCNSL patients were identified. Results: The studies that assessed cognitive functions after whole-brain radiotherapy combined with chemotherapy reported cognitive impairment in most patients. Patients treated with chemotherapy alone had either stable or improved cognitive performance in most studies. Methodological problems, however, limited the ability to ascertain the specific contribution of disease and various treatment interventions to cognitive outcome. On the basis of the literature review, a battery of cognitive and quality-of-life (QoL) measures to be used in prospective clinical trials was proposed. The battery is composed of five standardized neuropsychological tests, covering four domains sensitive to disease and treatment effects (attention, executive functions, memory, psychomotor speed), and QoL questionnaires, and meets criteria for use in collaborative trials. Conclusion: The incorporation of formal and systematic cognitive evaluations in PCNSL studies will improve our understanding of treatment-related neurotoxicity in this population.

Original languageEnglish (US)
Pages (from-to)1145-1151
Number of pages7
JournalAnnals of Oncology
Volume18
Issue number7
DOIs
StatePublished - Jul 2007

Fingerprint

Cognition
Lymphoma
Central Nervous System
Guidelines
Quality of Life
Therapeutics
Drug Therapy
Aptitude
Neuropsychological Tests
Executive Function
Population
Radiotherapy
Survival Rate
Clinical Trials
Brain
Research

Keywords

  • Chemotherapy
  • Cognitive
  • Neurotoxicity
  • Primary CNS lymphoma
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Correa, D. D., Maron, L., Harder, H., Klein, M., Armstrong, C. L., Calabrese, P., ... Schiff, D. (2007). Cognitive functions in primary central nervous system lymphoma: Literature review and assessment guidelines. Annals of Oncology, 18(7), 1145-1151. https://doi.org/10.1093/annonc/mdl464

Cognitive functions in primary central nervous system lymphoma : Literature review and assessment guidelines. / Correa, D. D.; Maron, Leeza; Harder, H.; Klein, M.; Armstrong, C. L.; Calabrese, P.; Bromberg, J. E C; Abrey, L. E.; Batchelor, T. T.; Schiff, D.

In: Annals of Oncology, Vol. 18, No. 7, 07.2007, p. 1145-1151.

Research output: Contribution to journalArticle

Correa, DD, Maron, L, Harder, H, Klein, M, Armstrong, CL, Calabrese, P, Bromberg, JEC, Abrey, LE, Batchelor, TT & Schiff, D 2007, 'Cognitive functions in primary central nervous system lymphoma: Literature review and assessment guidelines', Annals of Oncology, vol. 18, no. 7, pp. 1145-1151. https://doi.org/10.1093/annonc/mdl464
Correa, D. D. ; Maron, Leeza ; Harder, H. ; Klein, M. ; Armstrong, C. L. ; Calabrese, P. ; Bromberg, J. E C ; Abrey, L. E. ; Batchelor, T. T. ; Schiff, D. / Cognitive functions in primary central nervous system lymphoma : Literature review and assessment guidelines. In: Annals of Oncology. 2007 ; Vol. 18, No. 7. pp. 1145-1151.
@article{f6aabf18fcdd4b9f9ad9f7206d1958b9,
title = "Cognitive functions in primary central nervous system lymphoma: Literature review and assessment guidelines",
abstract = "Background: Treatment-related neurotoxicity has been recognized as a significant problem in patients with primary central nervous system lymphoma (PCNSL) as effective treatment has increased survival rates. There is, however, a paucity of research on cognitive functions in this population. Design: In a review of the literature, a total of 17 articles that described cognitive outcome in adult PCNSL patients were identified. Results: The studies that assessed cognitive functions after whole-brain radiotherapy combined with chemotherapy reported cognitive impairment in most patients. Patients treated with chemotherapy alone had either stable or improved cognitive performance in most studies. Methodological problems, however, limited the ability to ascertain the specific contribution of disease and various treatment interventions to cognitive outcome. On the basis of the literature review, a battery of cognitive and quality-of-life (QoL) measures to be used in prospective clinical trials was proposed. The battery is composed of five standardized neuropsychological tests, covering four domains sensitive to disease and treatment effects (attention, executive functions, memory, psychomotor speed), and QoL questionnaires, and meets criteria for use in collaborative trials. Conclusion: The incorporation of formal and systematic cognitive evaluations in PCNSL studies will improve our understanding of treatment-related neurotoxicity in this population.",
keywords = "Chemotherapy, Cognitive, Neurotoxicity, Primary CNS lymphoma, Radiotherapy",
author = "Correa, {D. D.} and Leeza Maron and H. Harder and M. Klein and Armstrong, {C. L.} and P. Calabrese and Bromberg, {J. E C} and Abrey, {L. E.} and Batchelor, {T. T.} and D. Schiff",
year = "2007",
month = "7",
doi = "10.1093/annonc/mdl464",
language = "English (US)",
volume = "18",
pages = "1145--1151",
journal = "Annals of Oncology",
issn = "0923-7534",
publisher = "Oxford University Press",
number = "7",

}

TY - JOUR

T1 - Cognitive functions in primary central nervous system lymphoma

T2 - Literature review and assessment guidelines

AU - Correa, D. D.

AU - Maron, Leeza

AU - Harder, H.

AU - Klein, M.

AU - Armstrong, C. L.

AU - Calabrese, P.

AU - Bromberg, J. E C

AU - Abrey, L. E.

AU - Batchelor, T. T.

AU - Schiff, D.

PY - 2007/7

Y1 - 2007/7

N2 - Background: Treatment-related neurotoxicity has been recognized as a significant problem in patients with primary central nervous system lymphoma (PCNSL) as effective treatment has increased survival rates. There is, however, a paucity of research on cognitive functions in this population. Design: In a review of the literature, a total of 17 articles that described cognitive outcome in adult PCNSL patients were identified. Results: The studies that assessed cognitive functions after whole-brain radiotherapy combined with chemotherapy reported cognitive impairment in most patients. Patients treated with chemotherapy alone had either stable or improved cognitive performance in most studies. Methodological problems, however, limited the ability to ascertain the specific contribution of disease and various treatment interventions to cognitive outcome. On the basis of the literature review, a battery of cognitive and quality-of-life (QoL) measures to be used in prospective clinical trials was proposed. The battery is composed of five standardized neuropsychological tests, covering four domains sensitive to disease and treatment effects (attention, executive functions, memory, psychomotor speed), and QoL questionnaires, and meets criteria for use in collaborative trials. Conclusion: The incorporation of formal and systematic cognitive evaluations in PCNSL studies will improve our understanding of treatment-related neurotoxicity in this population.

AB - Background: Treatment-related neurotoxicity has been recognized as a significant problem in patients with primary central nervous system lymphoma (PCNSL) as effective treatment has increased survival rates. There is, however, a paucity of research on cognitive functions in this population. Design: In a review of the literature, a total of 17 articles that described cognitive outcome in adult PCNSL patients were identified. Results: The studies that assessed cognitive functions after whole-brain radiotherapy combined with chemotherapy reported cognitive impairment in most patients. Patients treated with chemotherapy alone had either stable or improved cognitive performance in most studies. Methodological problems, however, limited the ability to ascertain the specific contribution of disease and various treatment interventions to cognitive outcome. On the basis of the literature review, a battery of cognitive and quality-of-life (QoL) measures to be used in prospective clinical trials was proposed. The battery is composed of five standardized neuropsychological tests, covering four domains sensitive to disease and treatment effects (attention, executive functions, memory, psychomotor speed), and QoL questionnaires, and meets criteria for use in collaborative trials. Conclusion: The incorporation of formal and systematic cognitive evaluations in PCNSL studies will improve our understanding of treatment-related neurotoxicity in this population.

KW - Chemotherapy

KW - Cognitive

KW - Neurotoxicity

KW - Primary CNS lymphoma

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=34547840273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547840273&partnerID=8YFLogxK

U2 - 10.1093/annonc/mdl464

DO - 10.1093/annonc/mdl464

M3 - Article

VL - 18

SP - 1145

EP - 1151

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

IS - 7

ER -