TY - JOUR
T1 - Cognition, function, and prevalent dementia in centenarians and near-centenarians
T2 - An individual participant data (IPD) meta-analysis of 18 studies
AU - Leung, Yvonne
AU - Barzilai, Nir
AU - Batko-Szwaczka, Agnieszka
AU - Beker, Nina
AU - Boerner, Kathrin
AU - Brayne, Carol
AU - Brodaty, Henry
AU - Cheung, Karen Siu Lan
AU - Corrada, María M.
AU - Crawford, John D.
AU - Galbussera, Alessia A.
AU - Gondo, Yasuyuki
AU - Holstege, Henne
AU - Hulsman, Marc
AU - Ishioka, Yoshiko Lily
AU - Jopp, Daniela
AU - Kawas, Claudia H.
AU - Kaye, Jeff
AU - Kochan, Nicole A.
AU - Lau, Bobo Hi Po
AU - Lipnicki, Darren M.
AU - Lo, Jessica W.
AU - Lucca, Ugo
AU - Makkar, Steve R.
AU - Marcon, Gabriella
AU - Martin, Peter
AU - Meguro, Kenichi
AU - Milman, Sofiya
AU - Poon, Leonard W.
AU - Recchia, Angela
AU - Ribeiro, Oscar
AU - Riva, Emma
AU - Rott, Christoph
AU - Sikkes, Sietske A.M.
AU - Skoog, Ingmar
AU - Stephan, Blossom
AU - Szewieczek, Jan
AU - Teixeira, Laetitia
AU - Tettamanti, Mauro
AU - Wilczyński, Krzysztof
AU - Sachdev, Perminder
N1 - Publisher Copyright:
© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2023/6
Y1 - 2023/6
N2 - Introduction: There are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100. Methods: Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed. Results: The mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92–0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35–0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI). Discussion: Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.
AB - Introduction: There are limited data on prevalence of dementia in centenarians and near-centenarians (C/NC), its determinants, and whether the risk of dementia continues to rise beyond 100. Methods: Participant-level data were obtained from 18 community-based studies (N = 4427) in 11 countries that included individuals ≥95 years. A harmonization protocol was applied to cognitive and functional impairments, and a meta-analysis was performed. Results: The mean age was 98.3 years (SD = 2.67); 79% were women. After adjusting for age, sex, and education, dementia prevalence was 53.2% in women and 45.5% in men, with risk continuing to increase with age. Education (OR 0.95;0.92–0.98) was protective, as was hypertension (odds ratio [OR] 0.51;0.35–0.74) in five studies. Dementia was not associated with diabetes, vision and hearing impairments, smoking, and body mass index (BMI). Discussion: Among the exceptional old, dementia prevalence remains higher in the older participants. Education was protective against dementia, but other factors for dementia-free survival in C/NC remain to be understood.
KW - centenarians
KW - dementia
KW - education
KW - exceptional longevity
KW - prevalence
KW - risk factors
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U2 - 10.1002/alz.12828
DO - 10.1002/alz.12828
M3 - Article
C2 - 36453627
AN - SCOPUS:85143900298
SN - 1552-5260
VL - 19
SP - 2265
EP - 2275
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 6
ER -