Cochlear IgG in the C3H/lpr autoimmune strain mouse

Marc L. Wong, Jeffrey S. Young, Gajanan Nilaver, Jane I. Morton, Dennis Trune

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The inner ear of the C3H/lpr autoimmune strain mouse was evaluated to identify potential mechanisms by which systemic autoimmune disease interferes with auditory function. The inner ears were immunohistochemically stained for IgG at ages before (2 months) and after (6-10 months) autoimmune disease onset and compared to age-matched nonautoimmune C3H/HeJ controls. Immunoreactivity for IgG was not seen in the 2 month C3H/lpr autoimmune mice or in either age group of the C3H/HeJ controls. On the other hand, all older C3H/lpr mice showed reaction product in the vessels of the cochlea, particularly the stria vascularis and bony capsule. Less frequent sites of staining were the geniculate ganglion, marrow cavities of the bony capsule, tensor tympani muscle, and on one occasion, a hair cell of the organ of Corti. These findings indicate that IgG is widespread within the cochlea and its vessels during systemic autoimmune disease and not directed against any specific sensorineural structure. This suggests a generalized or indirect mechanism whereby such systemic disease affects the inner ear.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalHearing Research
Volume59
Issue number1
DOIs
StatePublished - 1992

Fingerprint

Cochlea
Autoimmune Diseases
Immunoglobulin G
Inner Ear
Capsules
Tensor Tympani
Geniculate Ganglion
Labyrinth Diseases
Stria Vascularis
Organ of Corti
Inbred C3H Mouse
Age Groups
Bone Marrow
Staining and Labeling
Muscles

Keywords

  • Autoimmune disease
  • Immunoglobulin G
  • Inner ear
  • lpr gene
  • Mouse

ASJC Scopus subject areas

  • Sensory Systems

Cite this

Cochlear IgG in the C3H/lpr autoimmune strain mouse. / Wong, Marc L.; Young, Jeffrey S.; Nilaver, Gajanan; Morton, Jane I.; Trune, Dennis.

In: Hearing Research, Vol. 59, No. 1, 1992, p. 93-100.

Research output: Contribution to journalArticle

Wong, ML, Young, JS, Nilaver, G, Morton, JI & Trune, D 1992, 'Cochlear IgG in the C3H/lpr autoimmune strain mouse', Hearing Research, vol. 59, no. 1, pp. 93-100. https://doi.org/10.1016/0378-5955(92)90106-W
Wong, Marc L. ; Young, Jeffrey S. ; Nilaver, Gajanan ; Morton, Jane I. ; Trune, Dennis. / Cochlear IgG in the C3H/lpr autoimmune strain mouse. In: Hearing Research. 1992 ; Vol. 59, No. 1. pp. 93-100.
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