Cochlear cytokine gene expression in murine chronic otitis media

Bobak A. Ghaheri, J. Beth Kempton, De Ann M Pillers, Dennis Trune

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To investigate chronic otitis media (COM) induction of cochlear cytokine genes. Study Design: RNA from cochleas of five C3H/HeJ mice with and without COM was isolated for cytokine expression in gene arrays. Immunohistochemistry was performed for the protein products of up-regulated genes to confirm their expression in cochlear tissues. Results: Cochleas from COM mice showed increased expression of 29 genes (>2× normal) and decreased expression of 19 genes (

Original languageEnglish (US)
Pages (from-to)332-337
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Volume137
Issue number2
DOIs
StatePublished - Aug 2007

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Cochlea
Otitis Media
Cytokines
Gene Expression
Inbred C3H Mouse
Genes
Immunohistochemistry
RNA
Proteins

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Cochlear cytokine gene expression in murine chronic otitis media. / Ghaheri, Bobak A.; Kempton, J. Beth; Pillers, De Ann M; Trune, Dennis.

In: Otolaryngology - Head and Neck Surgery, Vol. 137, No. 2, 08.2007, p. 332-337.

Research output: Contribution to journalArticle

Ghaheri, Bobak A. ; Kempton, J. Beth ; Pillers, De Ann M ; Trune, Dennis. / Cochlear cytokine gene expression in murine chronic otitis media. In: Otolaryngology - Head and Neck Surgery. 2007 ; Vol. 137, No. 2. pp. 332-337.
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