Cochlear blood flow in response to dilating agents

K. Agnetha Ohlsén, Anne Didier, David Baldwin, Josef M. Miller, Alfred Nuttall, Elisabeth Hultcrantz

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Reduced cochlear blood flow (CBF) has been implicated in various pathologies of the inner ear, including sudden deafness, noise-induced hearing loss and Meniere's disease. Thus the aim of some current therapeutic regimens to treat these conditions is to increase CBF and thereby improve oxygenation of the inner ear tissues. Most of the vasodilating agents in clinical use, however, do not have specific experimental evidence to support their effects on CBF. The hypotension which can follow systemic administration may limit their local effectiveness and general utility, just as it complicates the interpretation of the data in animal experiments. In the current study we investigated the effect of six agents, known for their systemic cardiovascular actions, on CBF: hydralazine, sodium nitroprusside, papaverine, nicotinic acid, verapamil and histamine. The effect of these drugs was studied after topical applications on the round window membrane (RWM) and systemic intravenous administrations. CBF was monitored with a laser Doppler flowmeter (LDF). Topical administration of sodium nitroprusside was the most effective in increasing CBF, followed, in order, by hydralazine and histamine. No change in CBF was observed for papaverine, verapamil or nicotinic acid. Systemic administrations of all the agents caused a marked decrease in blood pressure and variable effects on CBF. We discuss the CBF changes in relation to the different pharmacological mechanisms of action of each drug. The study demonstrates the effectiveness of topical application of vasodilating agents in increasing CBF.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalHearing Research
Volume58
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Cochlea
Hydralazine
Papaverine
Niacin
Nitroprusside
Inner Ear
Verapamil
Histamine
Molecular Mechanisms of Pharmacological Action
Noise-Induced Hearing Loss
Sudden Hearing Loss
Topical Administration
Flowmeters
Meniere Disease
Pharmaceutical Preparations
Intravenous Administration
Hypotension
Lasers
Pathology
Blood Pressure

Keywords

  • Guinea pig
  • Histamine
  • Hydralazine
  • Nicotinic acid
  • Papaverine
  • Sodium nitroprusside
  • Verapamil

ASJC Scopus subject areas

  • Sensory Systems

Cite this

Ohlsén, K. A., Didier, A., Baldwin, D., Miller, J. M., Nuttall, A., & Hultcrantz, E. (1992). Cochlear blood flow in response to dilating agents. Hearing Research, 58(1), 19-25. https://doi.org/10.1016/0378-5955(92)90004-7

Cochlear blood flow in response to dilating agents. / Ohlsén, K. Agnetha; Didier, Anne; Baldwin, David; Miller, Josef M.; Nuttall, Alfred; Hultcrantz, Elisabeth.

In: Hearing Research, Vol. 58, No. 1, 1992, p. 19-25.

Research output: Contribution to journalArticle

Ohlsén, KA, Didier, A, Baldwin, D, Miller, JM, Nuttall, A & Hultcrantz, E 1992, 'Cochlear blood flow in response to dilating agents', Hearing Research, vol. 58, no. 1, pp. 19-25. https://doi.org/10.1016/0378-5955(92)90004-7
Ohlsén, K. Agnetha ; Didier, Anne ; Baldwin, David ; Miller, Josef M. ; Nuttall, Alfred ; Hultcrantz, Elisabeth. / Cochlear blood flow in response to dilating agents. In: Hearing Research. 1992 ; Vol. 58, No. 1. pp. 19-25.
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