Coccidioidomycosis in adolescents with lupus nephritis

P. D. Yorgin, M. Rewari, A. Y. Al-Uzri, A. A. Theodorou, K. M. Scott, L. L. Barton

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Coccidioidomycosis, a fungal infection endemic in the southwestern United States, can cause life-threatening infections in immunosuppressed patients. We report the contrasting cases of two adolescents with lupus nephritis, treated with intravenous pulse cyclophosphamide and daily oral corticosteroids, who developed pulmonary coccidioidomycosis. One patient developed a fatal form of fulminant disseminated coccidioidomycosis, while the other patient developed a solitary pulmonary coccidioides immitis abscess which was responsive to intravenous liposomal amphotericin and fluconazole therapy. Because serologies and initial X-ray studies can be negative, definitive diagnostic studies including bronchioaveolar lavage and needle aspiration should be performed when there is clinical suspicion of coccidioidomycosis in an immunocompromised patient. Immunosuppressed patients with coccidioidomycosis should receive early intravenous amphotericin therapy and may benefit from long-term suppressive antifungal therapy to prevent relapse.

Original languageEnglish (US)
Pages (from-to)77-81
Number of pages5
JournalPediatric Nephrology
Volume16
Issue number1
DOIs
StatePublished - Jan 1 2001

Keywords

  • Adolescent
  • Amphotericin
  • Coccidioidomycosis
  • Fluconazole
  • Liposomal amphotericin
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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  • Cite this

    Yorgin, P. D., Rewari, M., Al-Uzri, A. Y., Theodorou, A. A., Scott, K. M., & Barton, L. L. (2001). Coccidioidomycosis in adolescents with lupus nephritis. Pediatric Nephrology, 16(1), 77-81. https://doi.org/10.1007/s004670000468