Cocaine induced synchronous oscillations in central noradrenergic neurons In vitro

G. C. Harris, Z. E. Hausken, John Williams

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Through inhibition of reuptake, cocaine increases monoaminergic tone in the central nervous system.4 The activities of the neurons within the locus coeruleus play a pivotal role in central noradrenergic transmission and regulate overall levels of arousal and attention.3,10 We have found that cocaine in low concentrations (0.3-1.0 μM) induced slow oscillations (0.8 Hz) in membrane potential (2-6 mV). These oscillations were synchronized in neurons throughout the nucleus and were blocked by α2-adrenergic receptor antagonists. The synchrony of these events was thought to arise from within the nucleus, through a combination of spontaneous activity (intrinsic properties) 24 and noradrenergic mediated inhibitory postsynaptic potentials6,7 augmented by cocaine. The synchronous firing of noradrenergic neurons may facilitate transmitter release in the widespread projection areas and thus be important for the action of cocaine to increase levels of arousal.23.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalNeuroscience
Volume50
Issue number2
DOIs
StatePublished - 1992

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Adrenergic Neurons
Cocaine
Neurons
Adrenergic Antagonists
Locus Coeruleus
Arousal
Membrane Potentials
In Vitro Techniques

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cocaine induced synchronous oscillations in central noradrenergic neurons In vitro. / Harris, G. C.; Hausken, Z. E.; Williams, John.

In: Neuroscience, Vol. 50, No. 2, 1992, p. 253-257.

Research output: Contribution to journalArticle

Harris, G. C. ; Hausken, Z. E. ; Williams, John. / Cocaine induced synchronous oscillations in central noradrenergic neurons In vitro. In: Neuroscience. 1992 ; Vol. 50, No. 2. pp. 253-257.
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