Cocaine induced synchronous oscillations in central noradrenergic neurons In vitro

G. C. Harris; Z. E. Hausken; J. T. Williams

doi:10.1016/0306-4522(92)90420-7

Cocaine induced synchronous oscillations in central noradrenergic neurons In vitro

G. C. Harris, Z. E. Hausken, J. T. Williams

Vollum Institute

Research output: Contribution to journal › Article › peer-review

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Abstract

Through inhibition of reuptake, cocaine increases monoaminergic tone in the central nervous system.⁴ The activities of the neurons within the locus coeruleus play a pivotal role in central noradrenergic transmission and regulate overall levels of arousal and attention.^3,10 We have found that cocaine in low concentrations (0.3-1.0 μM) induced slow oscillations (0.8 Hz) in membrane potential (2-6 mV). These oscillations were synchronized in neurons throughout the nucleus and were blocked by α₂-adrenergic receptor antagonists. The synchrony of these events was thought to arise from within the nucleus, through a combination of spontaneous activity (intrinsic properties) ²⁴ and noradrenergic mediated inhibitory postsynaptic potentials^6,7 augmented by cocaine. The synchronous firing of noradrenergic neurons may facilitate transmitter release in the widespread projection areas and thus be important for the action of cocaine to increase levels of arousal.²³.

Original language	English (US)
Pages (from-to)	253-257
Number of pages	5
Journal	Neuroscience
Volume	50
Issue number	2
DOIs	https://doi.org/10.1016/0306-4522(92)90420-7
State	Published - Sep 1992

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0306-4522(92)90420-7

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@article{9de7af58c99149bb962293b3036535e0,

title = "Cocaine induced synchronous oscillations in central noradrenergic neurons In vitro",

abstract = "Through inhibition of reuptake, cocaine increases monoaminergic tone in the central nervous system.4 The activities of the neurons within the locus coeruleus play a pivotal role in central noradrenergic transmission and regulate overall levels of arousal and attention.3,10 We have found that cocaine in low concentrations (0.3-1.0 μM) induced slow oscillations (0.8 Hz) in membrane potential (2-6 mV). These oscillations were synchronized in neurons throughout the nucleus and were blocked by α2-adrenergic receptor antagonists. The synchrony of these events was thought to arise from within the nucleus, through a combination of spontaneous activity (intrinsic properties) 24 and noradrenergic mediated inhibitory postsynaptic potentials6,7 augmented by cocaine. The synchronous firing of noradrenergic neurons may facilitate transmitter release in the widespread projection areas and thus be important for the action of cocaine to increase levels of arousal.23.",

author = "Harris, {G. C.} and Hausken, {Z. E.} and Williams, {J. T.}",

note = "Funding Information: Acknowh, dgements--We thank Drs C. Jahr, P. Osborne, D. Cameron and R. Shiekhattar for helpful comments on the manuscript and work. The work was supported by National Institute on Drug Abuse (NIDA) grants DA04523 and DA00141 to JTW and DA05487 to GCH.",

year = "1992",

month = sep,

doi = "10.1016/0306-4522(92)90420-7",

language = "English (US)",

volume = "50",

pages = "253--257",

journal = "Neuroscience",

issn = "0306-4522",

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T1 - Cocaine induced synchronous oscillations in central noradrenergic neurons In vitro

AU - Harris, G. C.

AU - Hausken, Z. E.

AU - Williams, J. T.

N1 - Funding Information: Acknowh, dgements--We thank Drs C. Jahr, P. Osborne, D. Cameron and R. Shiekhattar for helpful comments on the manuscript and work. The work was supported by National Institute on Drug Abuse (NIDA) grants DA04523 and DA00141 to JTW and DA05487 to GCH.

PY - 1992/9

Y1 - 1992/9

N2 - Through inhibition of reuptake, cocaine increases monoaminergic tone in the central nervous system.4 The activities of the neurons within the locus coeruleus play a pivotal role in central noradrenergic transmission and regulate overall levels of arousal and attention.3,10 We have found that cocaine in low concentrations (0.3-1.0 μM) induced slow oscillations (0.8 Hz) in membrane potential (2-6 mV). These oscillations were synchronized in neurons throughout the nucleus and were blocked by α2-adrenergic receptor antagonists. The synchrony of these events was thought to arise from within the nucleus, through a combination of spontaneous activity (intrinsic properties) 24 and noradrenergic mediated inhibitory postsynaptic potentials6,7 augmented by cocaine. The synchronous firing of noradrenergic neurons may facilitate transmitter release in the widespread projection areas and thus be important for the action of cocaine to increase levels of arousal.23.

AB - Through inhibition of reuptake, cocaine increases monoaminergic tone in the central nervous system.4 The activities of the neurons within the locus coeruleus play a pivotal role in central noradrenergic transmission and regulate overall levels of arousal and attention.3,10 We have found that cocaine in low concentrations (0.3-1.0 μM) induced slow oscillations (0.8 Hz) in membrane potential (2-6 mV). These oscillations were synchronized in neurons throughout the nucleus and were blocked by α2-adrenergic receptor antagonists. The synchrony of these events was thought to arise from within the nucleus, through a combination of spontaneous activity (intrinsic properties) 24 and noradrenergic mediated inhibitory postsynaptic potentials6,7 augmented by cocaine. The synchronous firing of noradrenergic neurons may facilitate transmitter release in the widespread projection areas and thus be important for the action of cocaine to increase levels of arousal.23.

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DO - 10.1016/0306-4522(92)90420-7

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VL - 50

SP - 253

EP - 257

JO - Neuroscience

JF - Neuroscience

IS - 2

ER -

Cocaine induced synchronous oscillations in central noradrenergic neurons In vitro

Abstract

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