Cocaine-induced myocardial ischemia and infarction: Pathophysiology, recognition, and management

W. R. Pitts, R. A. Lange, J. E. Cigarroa, L. D. Hillis

    Research output: Contribution to journalArticlepeer-review

    110 Scopus citations


    As cocaine abuse has become widespread, it has been associated with various cardiovascular complications, including angina pectoris, myocardial infarction, and sudden cardiac death. Cocaine's principal effects on the cardiovascular system are mediated via α-adrenergic stimulation and include (1) an increase in the determinants of myocardial oxygen demand (heart rate and systemic arterial pressure), and (2) a concomitant decrease in myocardial oxygen supply (caused by vasoconstriction of the epicardial coronary arteries). β-adrenergic blocking agents may exacerbate cocaine-induced coronary arterial vasoconstriction, thereby increasing the magnitude of myocardial ischemia. In contrast, nitroglycerin and verapamil reverse cocaine-induced hypertension and coronary arterial vasoconstriction; therefore, they are the agents of choice in treating patients with cocaine- associated chest pain.

    Original languageEnglish (US)
    Pages (from-to)65-76
    Number of pages12
    JournalProgress in Cardiovascular Diseases
    Issue number1
    StatePublished - Jan 1 1997

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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