Cocaine-induced adaptation of dopamine D2S, but not D2L autoreceptors

Brooks G. Robinson, Alec F. Condon, Daniela Radl, Emiliana Borrelli, John Williams, Kim Neve

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The dopamine D2 receptor has two splice variants, D2S (Short) and D2L (Long). In dopamine neurons, both variants can act as autoreceptors to regulate neuronal excitability and dopamine release, but the roles of each variant are incompletely characterized. In a previous study we used viral receptor expression in D2 receptor knockout mice to show distinct effects of calcium signaling on D2S and D2L autoreceptor function (Gantz et al., 2015). However, the cocaine-induced plasticity of D2 receptor desensitization observed in wild type mice was not recapitulated with this method of receptor expression. Here we use mice with genetic knockouts of either the D2S or D2L variant to investigate cocaine-induced plasticity in D2 receptor signaling. Following a single in vivo cocaine exposure, the desensitization of D2 receptors from neurons expressing only the D2S variant was reduced. This did not occur in D2L-expressing neurons, indicating differential druginduced plasticity between the variants.

Original languageEnglish (US)
Article numbere31924
JournaleLife
Volume6
DOIs
Publication statusPublished - Nov 20 2017

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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