Cocaine impairs gonadotropin secretion in oophorectomized monkeys

Melin S. Cañez, Mary Samuels, Michael F. Luther, Thomas S. King, Robert S. Schenken

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

OBJECTIVE: Our objective was to determine whether cocaine alters gonadotropin secretion in oophorectomized monkeys. STUDY DESIGN: Oophorectomized monkeys with elevated gonadotropin levels were chronically cannulated to allow blood sampling every 15 minutes. Monkeys received either saline solution or 2 or 4 mg/kg cocaine hydrochloride as an intravenous bolus. Other oophorectomized monkeys were pretreated with either saline solution or 4 mg/kg cocaine 2 hours before bolus gonadotropin-releasing hormone administration, and plasma luteinizing hormone and follicle-stimulating hormone levels were measured every 15 minutes for 3 hours. Monkeys were also given either saline solution or 4 mg/kg of cocaine with gonadotropin-releasing hormone simultaneously, and plasma gonadotropin levels were measured every 15 minutes for 3 hours. Serum luteinizing hormone and follicle-stimulating hormone levels were measured by radioimmunoassay. RESULTS: Both doses of cocaine resulted in a significant decrease in luteinizing hormone levels compared with controls. Follicle-stimulating hormone levels were significantly decreased only with the 4 mg/kg dose of cocaine. There was no difference in luteinizing hormone and follicle-stimulating hormone responses to gonadotropin-releasing hormone in the cocaine-treated monkeys compared with saline solution treated monkeys by using repeated-measures analysis of variance. CONCLUSION: These findings demonstrate that acute cocaine administration to oophorectomized primates inhibits basal luteinizing hormone-follicle-stimulating hormone secretion but not gonadotropin-releasing hormone-stimulated luteinizing hormone and follicle-stimulating hormone release. In the absence of an effect on gonadotropin-releasing hormone-stimulated gonadotropin release, we conclude that the impaired lutelnizing hormone-follicle-stimulating hormone secretion after cocaine administration is due in part to a direct effect of cocaine on gonadotropin-releasing hormone neurons or on hypothalamic neurotransmitter modulation of gonadotropin-releasing hormone release.

Original languageEnglish (US)
Pages (from-to)1785-1793
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Volume167
Issue number6
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Gonadotropins
Cocaine
Haplorhini
Follicle Stimulating Hormone
Gonadotropin-Releasing Hormone
Luteinizing Hormone
Sodium Chloride
Primates
Radioimmunoassay
Neurotransmitter Agents
Analysis of Variance
Hormones
Neurons
Serum

Keywords

  • Cocaine
  • primates
  • reproductive dysfunction

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Cocaine impairs gonadotropin secretion in oophorectomized monkeys. / Cañez, Melin S.; Samuels, Mary; Luther, Michael F.; King, Thomas S.; Schenken, Robert S.

In: American Journal of Obstetrics and Gynecology, Vol. 167, No. 6, 1992, p. 1785-1793.

Research output: Contribution to journalArticle

Cañez, Melin S. ; Samuels, Mary ; Luther, Michael F. ; King, Thomas S. ; Schenken, Robert S. / Cocaine impairs gonadotropin secretion in oophorectomized monkeys. In: American Journal of Obstetrics and Gynecology. 1992 ; Vol. 167, No. 6. pp. 1785-1793.
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