Coagulation management in Massive bleeding

Matthew J. Griffee, Thomas Deloughery, Per Thorborg

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    Purpose of review: To update readers on recent literature regarding treatment of coagulopathy for patients with life-threatening bleeding, highlighting emerging therapeutic options, controversial topics, and ongoing clinical trials. Recent findings: Massive transfusion protocols featuring immediate availability of blood products and multidisciplinary communication reduce mortality and conserve resources. There is a growing consensus that immediate administration of plasma and platelet units in a 1:1: 1 ratio with red cell units reduces early mortality. Lyophilized and recombinant blood product components may have advantages over traditional blood products in certain clinical circumstances. Summary: Massive transfusion protocols standardize treatment of the coagulopathy of massive bleeding, leading to rapid restoration of hemostasis and decrease in early mortality.

    Original languageEnglish (US)
    Pages (from-to)263-268
    Number of pages6
    JournalCurrent Opinion in Anaesthesiology
    Volume23
    Issue number2
    DOIs
    StatePublished - Apr 2010

    Fingerprint

    Hemorrhage
    Mortality
    Interdisciplinary Communication
    Clinical Protocols
    Hemostasis
    Consensus
    Blood Platelets
    Clinical Trials
    Therapeutics

    Keywords

    • Acute coagulopathy of trauma
    • Damage control resuscitation
    • Massive transfusion protocol
    • Prothrombin complex concentrate
    • Recombinant factor VIIa

    ASJC Scopus subject areas

    • Anesthesiology and Pain Medicine

    Cite this

    Coagulation management in Massive bleeding. / Griffee, Matthew J.; Deloughery, Thomas; Thorborg, Per.

    In: Current Opinion in Anaesthesiology, Vol. 23, No. 2, 04.2010, p. 263-268.

    Research output: Contribution to journalArticle

    Griffee, Matthew J. ; Deloughery, Thomas ; Thorborg, Per. / Coagulation management in Massive bleeding. In: Current Opinion in Anaesthesiology. 2010 ; Vol. 23, No. 2. pp. 263-268.
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