Coagulation management in Massive bleeding

Matthew J. Griffee, Thomas G. DeLoughery, Per A. Thorborg

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Purpose of review: To update readers on recent literature regarding treatment of coagulopathy for patients with life-threatening bleeding, highlighting emerging therapeutic options, controversial topics, and ongoing clinical trials. Recent findings: Massive transfusion protocols featuring immediate availability of blood products and multidisciplinary communication reduce mortality and conserve resources. There is a growing consensus that immediate administration of plasma and platelet units in a 1:1: 1 ratio with red cell units reduces early mortality. Lyophilized and recombinant blood product components may have advantages over traditional blood products in certain clinical circumstances. Summary: Massive transfusion protocols standardize treatment of the coagulopathy of massive bleeding, leading to rapid restoration of hemostasis and decrease in early mortality.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalCurrent Opinion in Anaesthesiology
Issue number2
StatePublished - Apr 1 2010


  • Acute coagulopathy of trauma
  • Damage control resuscitation
  • Massive transfusion protocol
  • Prothrombin complex concentrate
  • Recombinant factor VIIa

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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