Coadministration of MK-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitization

Marina E. Wolf, Michael Jeziorski

Research output: Contribution to journalArticle

240 Scopus citations

Abstract

Although coadministration of N-methyl-d-aspartate (NMDA) antagonists has been reported to prevent behavioral sensitization to psychomotor stimulants, it has been suggested that this effect is transitory and that sensitization is unmasked after longer periods of drug abstinence. To test this, rats were coadministered either amphetamine, cocaine, or morphine with the NMDA antagonist MK-801 and tested for sensitization after 7-10 days of abstinence. No sensitization was observed, suggesting that NMDA antagonists do not transiently mask sensitization but instead interfere with long-term processes responsible for its development.

Original languageEnglish (US)
Pages (from-to)291-294
Number of pages4
JournalBrain research
Volume613
Issue number2
DOIs
StatePublished - Jun 11 1993

Keywords

  • Dopamine
  • Drug of abuse
  • Locomotion
  • NMDA receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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