Co-occurence of restless legs syndrome and Parkin mutations in two families

Susana Adel, Ana Djarmati, Kemal Kabakci, Irene Pichler, Cordula Eskelson, Thora Lohnau, Norman Kock, Katja Hedrich, Eberhard Schwinger, Patricia L. Kramer, Peter P. Pramstaller, Christine Klein

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32 Scopus citations

Abstract

Recent studies have suggested an association between restless legs syndrome (RLS) and Parkinson's disease (PD). We present a large multigenerational family and a smaller family with RLS. A Parkin mutation was found in 10 of 20 patients from both families with idiopathic RLS but was not considered causative. The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance of RLS was consistent with autosomal dominant transmission, and linkage analysis excluded all three known loci for RLS.

Original languageEnglish (US)
Pages (from-to)258-263
Number of pages6
JournalMovement Disorders
Volume21
Issue number2
DOIs
StatePublished - Feb 2006

Keywords

  • Genetics
  • Parkin
  • Restless legs syndrome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Adel, S., Djarmati, A., Kabakci, K., Pichler, I., Eskelson, C., Lohnau, T., Kock, N., Hedrich, K., Schwinger, E., Kramer, P. L., Pramstaller, P. P., & Klein, C. (2006). Co-occurence of restless legs syndrome and Parkin mutations in two families. Movement Disorders, 21(2), 258-263. https://doi.org/10.1002/mds.20690