Co-occurence of restless legs syndrome and Parkin mutations in two families

Susana Adel; Ana Djarmati; Kemal Kabakci; Irene Pichler; Cordula Eskelson; Thora Lohnau; Norman Kock; Katja Hedrich; Eberhard Schwinger; Patricia L. Kramer; Peter P. Pramstaller; Christine Klein

doi:10.1002/mds.20690

Co-occurence of restless legs syndrome and Parkin mutations in two families

Susana Adel, Ana Djarmati, Kemal Kabakci, Irene Pichler, Cordula Eskelson, Thora Lohnau, Norman Kock, Katja Hedrich, Eberhard Schwinger, Patricia L. Kramer, Peter P. Pramstaller, Christine Klein

Neurology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Recent studies have suggested an association between restless legs syndrome (RLS) and Parkinson's disease (PD). We present a large multigenerational family and a smaller family with RLS. A Parkin mutation was found in 10 of 20 patients from both families with idiopathic RLS but was not considered causative. The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance of RLS was consistent with autosomal dominant transmission, and linkage analysis excluded all three known loci for RLS.

Original language	English (US)
Pages (from-to)	258-263
Number of pages	6
Journal	Movement Disorders
Volume	21
Issue number	2
DOIs	https://doi.org/10.1002/mds.20690
State	Published - Feb 2006

Keywords

Genetics
Parkin
Restless legs syndrome

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.20690

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title = "Co-occurence of restless legs syndrome and Parkin mutations in two families",

abstract = "Recent studies have suggested an association between restless legs syndrome (RLS) and Parkinson's disease (PD). We present a large multigenerational family and a smaller family with RLS. A Parkin mutation was found in 10 of 20 patients from both families with idiopathic RLS but was not considered causative. The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance of RLS was consistent with autosomal dominant transmission, and linkage analysis excluded all three known loci for RLS.",

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author = "Susana Adel and Ana Djarmati and Kemal Kabakci and Irene Pichler and Cordula Eskelson and Thora Lohnau and Norman Kock and Katja Hedrich and Eberhard Schwinger and Kramer, {Patricia L.} and Pramstaller, {Peter P.} and Christine Klein",

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T1 - Co-occurence of restless legs syndrome and Parkin mutations in two families

AU - Adel, Susana

AU - Djarmati, Ana

AU - Kabakci, Kemal

AU - Pichler, Irene

AU - Eskelson, Cordula

AU - Lohnau, Thora

AU - Kock, Norman

AU - Hedrich, Katja

AU - Schwinger, Eberhard

AU - Kramer, Patricia L.

AU - Pramstaller, Peter P.

AU - Klein, Christine

PY - 2006/2

Y1 - 2006/2

N2 - Recent studies have suggested an association between restless legs syndrome (RLS) and Parkinson's disease (PD). We present a large multigenerational family and a smaller family with RLS. A Parkin mutation was found in 10 of 20 patients from both families with idiopathic RLS but was not considered causative. The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance of RLS was consistent with autosomal dominant transmission, and linkage analysis excluded all three known loci for RLS.

AB - Recent studies have suggested an association between restless legs syndrome (RLS) and Parkinson's disease (PD). We present a large multigenerational family and a smaller family with RLS. A Parkin mutation was found in 10 of 20 patients from both families with idiopathic RLS but was not considered causative. The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance of RLS was consistent with autosomal dominant transmission, and linkage analysis excluded all three known loci for RLS.

KW - Genetics

KW - Parkin

KW - Restless legs syndrome

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JO - Movement Disorders

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ER -

Co-occurence of restless legs syndrome and Parkin mutations in two families

Abstract

Keywords

ASJC Scopus subject areas

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