Co-induction of activity-dependent genes in songbirds

Tarciso A F Velho, Raphael Pinaud, Paulo V. Rodrigues, Claudio Mello

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Song behavior in songbirds induces the expression of activity-dependent genes in brain areas involved in perceptual processing, production and learning of song. This genomic response is thought to represent a link between neuronal activation and long-term changes in song-processing circuits of the songbird brain. Here we demonstrate that Arc, an activity-regulated gene whose product has dendritic localization and is associated with synaptic plasticity, is rapidly induced by song in the brain of zebra finches. We show that, in the context of song auditory stimulation, Arc expression is induced in several telencephalic auditory areas, most prominently the caudomedial nidopallium and mesopallium, whereas in the context of singing, Arc is also induced in song control areas, namely nucleus HVC, used as a proper name, the robust nucleus of the arcopallium and the interface nucleus of the nidopallium. We also show that song-induced Arc expression co-localizes at the cellular level with those of the transcriptional regulators zenk and c-fos, and that the song induction of these three genes is dependent on activation of the mitogen-activated protein kinase signaling pathway. These findings provide evidence for an involvement of Arc in the brain's response to birdsong. They also demonstrate that genes representing distinct genomic and cellular regulatory programs, namely early effectors and transcription factors, are co-activated in the same neuronal cells by a naturally learned stimulus.

Original languageEnglish (US)
Pages (from-to)1667-1678
Number of pages12
JournalEuropean Journal of Neuroscience
Volume22
Issue number7
DOIs
StatePublished - Oct 2005

Fingerprint

Songbirds
Music
Genes
Brain
Finches
Acoustic Stimulation
Singing
Telencephalon
Auditory Cortex
Neuronal Plasticity
Equidae
Mitogen-Activated Protein Kinases
Names
Transcription Factors
Learning

Keywords

  • Arc
  • Birdsong
  • c-fos
  • Plasticity
  • Telencephalic auditory areas
  • Vocal learning
  • Zenk

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Co-induction of activity-dependent genes in songbirds. / Velho, Tarciso A F; Pinaud, Raphael; Rodrigues, Paulo V.; Mello, Claudio.

In: European Journal of Neuroscience, Vol. 22, No. 7, 10.2005, p. 1667-1678.

Research output: Contribution to journalArticle

Velho, Tarciso A F ; Pinaud, Raphael ; Rodrigues, Paulo V. ; Mello, Claudio. / Co-induction of activity-dependent genes in songbirds. In: European Journal of Neuroscience. 2005 ; Vol. 22, No. 7. pp. 1667-1678.
@article{aaf06b36887f48e9b97630fc131a4e95,
title = "Co-induction of activity-dependent genes in songbirds",
abstract = "Song behavior in songbirds induces the expression of activity-dependent genes in brain areas involved in perceptual processing, production and learning of song. This genomic response is thought to represent a link between neuronal activation and long-term changes in song-processing circuits of the songbird brain. Here we demonstrate that Arc, an activity-regulated gene whose product has dendritic localization and is associated with synaptic plasticity, is rapidly induced by song in the brain of zebra finches. We show that, in the context of song auditory stimulation, Arc expression is induced in several telencephalic auditory areas, most prominently the caudomedial nidopallium and mesopallium, whereas in the context of singing, Arc is also induced in song control areas, namely nucleus HVC, used as a proper name, the robust nucleus of the arcopallium and the interface nucleus of the nidopallium. We also show that song-induced Arc expression co-localizes at the cellular level with those of the transcriptional regulators zenk and c-fos, and that the song induction of these three genes is dependent on activation of the mitogen-activated protein kinase signaling pathway. These findings provide evidence for an involvement of Arc in the brain's response to birdsong. They also demonstrate that genes representing distinct genomic and cellular regulatory programs, namely early effectors and transcription factors, are co-activated in the same neuronal cells by a naturally learned stimulus.",
keywords = "Arc, Birdsong, c-fos, Plasticity, Telencephalic auditory areas, Vocal learning, Zenk",
author = "Velho, {Tarciso A F} and Raphael Pinaud and Rodrigues, {Paulo V.} and Claudio Mello",
year = "2005",
month = "10",
doi = "10.1111/j.1460-9568.2005.04369.x",
language = "English (US)",
volume = "22",
pages = "1667--1678",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Co-induction of activity-dependent genes in songbirds

AU - Velho, Tarciso A F

AU - Pinaud, Raphael

AU - Rodrigues, Paulo V.

AU - Mello, Claudio

PY - 2005/10

Y1 - 2005/10

N2 - Song behavior in songbirds induces the expression of activity-dependent genes in brain areas involved in perceptual processing, production and learning of song. This genomic response is thought to represent a link between neuronal activation and long-term changes in song-processing circuits of the songbird brain. Here we demonstrate that Arc, an activity-regulated gene whose product has dendritic localization and is associated with synaptic plasticity, is rapidly induced by song in the brain of zebra finches. We show that, in the context of song auditory stimulation, Arc expression is induced in several telencephalic auditory areas, most prominently the caudomedial nidopallium and mesopallium, whereas in the context of singing, Arc is also induced in song control areas, namely nucleus HVC, used as a proper name, the robust nucleus of the arcopallium and the interface nucleus of the nidopallium. We also show that song-induced Arc expression co-localizes at the cellular level with those of the transcriptional regulators zenk and c-fos, and that the song induction of these three genes is dependent on activation of the mitogen-activated protein kinase signaling pathway. These findings provide evidence for an involvement of Arc in the brain's response to birdsong. They also demonstrate that genes representing distinct genomic and cellular regulatory programs, namely early effectors and transcription factors, are co-activated in the same neuronal cells by a naturally learned stimulus.

AB - Song behavior in songbirds induces the expression of activity-dependent genes in brain areas involved in perceptual processing, production and learning of song. This genomic response is thought to represent a link between neuronal activation and long-term changes in song-processing circuits of the songbird brain. Here we demonstrate that Arc, an activity-regulated gene whose product has dendritic localization and is associated with synaptic plasticity, is rapidly induced by song in the brain of zebra finches. We show that, in the context of song auditory stimulation, Arc expression is induced in several telencephalic auditory areas, most prominently the caudomedial nidopallium and mesopallium, whereas in the context of singing, Arc is also induced in song control areas, namely nucleus HVC, used as a proper name, the robust nucleus of the arcopallium and the interface nucleus of the nidopallium. We also show that song-induced Arc expression co-localizes at the cellular level with those of the transcriptional regulators zenk and c-fos, and that the song induction of these three genes is dependent on activation of the mitogen-activated protein kinase signaling pathway. These findings provide evidence for an involvement of Arc in the brain's response to birdsong. They also demonstrate that genes representing distinct genomic and cellular regulatory programs, namely early effectors and transcription factors, are co-activated in the same neuronal cells by a naturally learned stimulus.

KW - Arc

KW - Birdsong

KW - c-fos

KW - Plasticity

KW - Telencephalic auditory areas

KW - Vocal learning

KW - Zenk

UR - http://www.scopus.com/inward/record.url?scp=26944468278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26944468278&partnerID=8YFLogxK

U2 - 10.1111/j.1460-9568.2005.04369.x

DO - 10.1111/j.1460-9568.2005.04369.x

M3 - Article

C2 - 16197507

AN - SCOPUS:26944468278

VL - 22

SP - 1667

EP - 1678

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 7

ER -