Co-dependents: MR1-restricted MAIT cells and their antimicrobial function

Marielle C. Gold, David M. Lewinsohn

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Mucosal-associated invariant T (MAIT) cells are a unique T cell subset in mammals. They are present at high frequencies at mucosal tissue sites and have an intrinsic capacity to respond to microbial infections. The semi-invariant antigen recognition receptor of MAIT cells detects the non-polymorphic antigen-presenting molecule major histocompatibility complex class I-related protein 1 (MR1), which can bind microorganism-derived riboflavin metabolites. The striking evolutionary conservation in both the MR1 molecule and the MAIT T cell receptor suggests that strong selective pressures maintain this T cell pattern recognition system which detects microbial infection.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalNature Reviews Microbiology
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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