TY - JOUR
T1 - CMV and Immunosenescence
T2 - From basics to clinics
AU - Solana, Rafael
AU - Tarazona, Raquel
AU - Aiello, Allison E.
AU - Akbar, Arne N.
AU - Appay, Victor
AU - Beswick, Mark
AU - Bosch, Jos A.
AU - Campos, Carmen
AU - Cantisán, Sara
AU - Cicin-Sain, Luka
AU - Derhovanessian, Evelyna
AU - Ferrando-Martínez, Sara
AU - Frasca, Daniela
AU - Fulöp, Tamas
AU - Govind, Sheila
AU - Grubeck-Loebenstein, Beatrix
AU - Hill, Ann
AU - Hurme, Mikko
AU - Kern, Florian
AU - Larbi, Anis
AU - López-Botet, Miguel
AU - Maier, Andrea B.
AU - McElhaney, Janet E.
AU - Moss, Paul
AU - Naumova, Elissaveta
AU - Nikolich-Zugich, Janko
AU - Pera, Alejandra
AU - Rector, Jerrald L.
AU - Riddell, Natalie
AU - Sanchez-Correa, Beatriz
AU - Sansoni, Paolo
AU - Sauce, Delphine
AU - van Lier, Rene
AU - Wang, George C.
AU - Wills, Mark R.
AU - Zieliński, Maciej
AU - Pawelec, Graham
N1 - Funding Information:
The Workshop was partially supported by the University of Cordoba and the Spanish Ministry of Science (SAF2011-16169-E).
PY - 2012/10/31
Y1 - 2012/10/31
N2 - Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates " immunosenescence" . This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.
AB - Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates " immunosenescence" . This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.
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U2 - 10.1186/1742-4933-9-23
DO - 10.1186/1742-4933-9-23
M3 - Article
C2 - 23114110
AN - SCOPUS:84868252990
SN - 1742-4933
VL - 9
JO - Immunity and Ageing
JF - Immunity and Ageing
M1 - 23
ER -